Guignardones P–S, New Meroterpenoids from the Endophytic Fungus Guignardia mangiferae A348 Derived from the Medicinal Plant Smilax glabra

Four new meroterpenoids, guignardones P–S (1–4), and three known analogues (5–7) were isolated from the endophytic fungal strain Guignardia mangiferae A348. Their structures were elucidated on the basis of spectroscopic analysis and single crystal X-ray diffraction. All the isolated compounds were e...

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Detalles Bibliográficos
Autores principales: Sun, Zhang-Hua, Liang, Fa-Liang, Wu, Wen, Chen, Yu-Chan, Pan, Qing-Ling, Li, Hao-Hua, Ye, Wei, Liu, Hong-Xin, Li, Sai-Ni, Tan, Guo-Hui, Zhang, Wei-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332344/
https://www.ncbi.nlm.nih.gov/pubmed/26703548
http://dx.doi.org/10.3390/molecules201219890
Descripción
Sumario:Four new meroterpenoids, guignardones P–S (1–4), and three known analogues (5–7) were isolated from the endophytic fungal strain Guignardia mangiferae A348. Their structures were elucidated on the basis of spectroscopic analysis and single crystal X-ray diffraction. All the isolated compounds were evaluated for their inhibitory effects on SF-268, MCF-7, and NCI-H460 human cancer cell lines. Compounds 2 and 4 exhibited weak inhibitions of cell proliferation against MCF-7 cell line.

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