Guignardones P–S, New Meroterpenoids from the Endophytic Fungus Guignardia mangiferae A348 Derived from the Medicinal Plant Smilax glabra

Four new meroterpenoids, guignardones P–S (1–4), and three known analogues (5–7) were isolated from the endophytic fungal strain Guignardia mangiferae A348. Their structures were elucidated on the basis of spectroscopic analysis and single crystal X-ray diffraction. All the isolated compounds were e...

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Detalles Bibliográficos
Autores principales: Sun, Zhang-Hua, Liang, Fa-Liang, Wu, Wen, Chen, Yu-Chan, Pan, Qing-Ling, Li, Hao-Hua, Ye, Wei, Liu, Hong-Xin, Li, Sai-Ni, Tan, Guo-Hui, Zhang, Wei-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332344/
https://www.ncbi.nlm.nih.gov/pubmed/26703548
http://dx.doi.org/10.3390/molecules201219890
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author Sun, Zhang-Hua
Liang, Fa-Liang
Wu, Wen
Chen, Yu-Chan
Pan, Qing-Ling
Li, Hao-Hua
Ye, Wei
Liu, Hong-Xin
Li, Sai-Ni
Tan, Guo-Hui
Zhang, Wei-Min
author_facet Sun, Zhang-Hua
Liang, Fa-Liang
Wu, Wen
Chen, Yu-Chan
Pan, Qing-Ling
Li, Hao-Hua
Ye, Wei
Liu, Hong-Xin
Li, Sai-Ni
Tan, Guo-Hui
Zhang, Wei-Min
author_sort Sun, Zhang-Hua
collection PubMed
description Four new meroterpenoids, guignardones P–S (1–4), and three known analogues (5–7) were isolated from the endophytic fungal strain Guignardia mangiferae A348. Their structures were elucidated on the basis of spectroscopic analysis and single crystal X-ray diffraction. All the isolated compounds were evaluated for their inhibitory effects on SF-268, MCF-7, and NCI-H460 human cancer cell lines. Compounds 2 and 4 exhibited weak inhibitions of cell proliferation against MCF-7 cell line.
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spelling pubmed-63323442019-01-24 Guignardones P–S, New Meroterpenoids from the Endophytic Fungus Guignardia mangiferae A348 Derived from the Medicinal Plant Smilax glabra Sun, Zhang-Hua Liang, Fa-Liang Wu, Wen Chen, Yu-Chan Pan, Qing-Ling Li, Hao-Hua Ye, Wei Liu, Hong-Xin Li, Sai-Ni Tan, Guo-Hui Zhang, Wei-Min Molecules Communication Four new meroterpenoids, guignardones P–S (1–4), and three known analogues (5–7) were isolated from the endophytic fungal strain Guignardia mangiferae A348. Their structures were elucidated on the basis of spectroscopic analysis and single crystal X-ray diffraction. All the isolated compounds were evaluated for their inhibitory effects on SF-268, MCF-7, and NCI-H460 human cancer cell lines. Compounds 2 and 4 exhibited weak inhibitions of cell proliferation against MCF-7 cell line. MDPI 2015-12-21 /pmc/articles/PMC6332344/ /pubmed/26703548 http://dx.doi.org/10.3390/molecules201219890 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Sun, Zhang-Hua
Liang, Fa-Liang
Wu, Wen
Chen, Yu-Chan
Pan, Qing-Ling
Li, Hao-Hua
Ye, Wei
Liu, Hong-Xin
Li, Sai-Ni
Tan, Guo-Hui
Zhang, Wei-Min
Guignardones P–S, New Meroterpenoids from the Endophytic Fungus Guignardia mangiferae A348 Derived from the Medicinal Plant Smilax glabra
title Guignardones P–S, New Meroterpenoids from the Endophytic Fungus Guignardia mangiferae A348 Derived from the Medicinal Plant Smilax glabra
title_full Guignardones P–S, New Meroterpenoids from the Endophytic Fungus Guignardia mangiferae A348 Derived from the Medicinal Plant Smilax glabra
title_fullStr Guignardones P–S, New Meroterpenoids from the Endophytic Fungus Guignardia mangiferae A348 Derived from the Medicinal Plant Smilax glabra
title_full_unstemmed Guignardones P–S, New Meroterpenoids from the Endophytic Fungus Guignardia mangiferae A348 Derived from the Medicinal Plant Smilax glabra
title_short Guignardones P–S, New Meroterpenoids from the Endophytic Fungus Guignardia mangiferae A348 Derived from the Medicinal Plant Smilax glabra
title_sort guignardones p–s, new meroterpenoids from the endophytic fungus guignardia mangiferae a348 derived from the medicinal plant smilax glabra
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332344/
https://www.ncbi.nlm.nih.gov/pubmed/26703548
http://dx.doi.org/10.3390/molecules201219890
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