Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives

Betulonic acid belongs to the pentacyclic triterpenic derivative class and can be obtained through the selective oxidation of betulin. In this study we set obtaining several functionalized derivatives of this compound by its condensation with several amino compounds such as aminoguanidine, hydroxyla...

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Detalles Bibliográficos
Autores principales: Ledeţi, Ionuţ, Avram, Ştefana, Bercean, Vasile, Vlase, Gabriela, Vlase, Titus, Ledeţi, Adriana, Zupko, Istvan, Mioc, Marius, Şuta, Lenuţa-Maria, Şoica, Codruţa, Dehelean, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332361/
https://www.ncbi.nlm.nih.gov/pubmed/26694347
http://dx.doi.org/10.3390/molecules201219876
Descripción
Sumario:Betulonic acid belongs to the pentacyclic triterpenic derivative class and can be obtained through the selective oxidation of betulin. In this study we set obtaining several functionalized derivatives of this compound by its condensation with several amino compounds such as aminoguanidine, hydroxylamine, n-butylamine and thiosemicarbazide as our goal. The functionalization of the parent compound led to several molecules with antiproliferative potential, the most promising being 3–2-carbamothioylhydrazonolup-20(29)-en-28-oic acid.

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