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Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives
Betulonic acid belongs to the pentacyclic triterpenic derivative class and can be obtained through the selective oxidation of betulin. In this study we set obtaining several functionalized derivatives of this compound by its condensation with several amino compounds such as aminoguanidine, hydroxyla...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332361/ https://www.ncbi.nlm.nih.gov/pubmed/26694347 http://dx.doi.org/10.3390/molecules201219876 |
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| author | Ledeţi, Ionuţ Avram, Ştefana Bercean, Vasile Vlase, Gabriela Vlase, Titus Ledeţi, Adriana Zupko, Istvan Mioc, Marius Şuta, Lenuţa-Maria Şoica, Codruţa Dehelean, Cristina |
| author_facet | Ledeţi, Ionuţ Avram, Ştefana Bercean, Vasile Vlase, Gabriela Vlase, Titus Ledeţi, Adriana Zupko, Istvan Mioc, Marius Şuta, Lenuţa-Maria Şoica, Codruţa Dehelean, Cristina |
| author_sort | Ledeţi, Ionuţ |
| collection | PubMed |
| description | Betulonic acid belongs to the pentacyclic triterpenic derivative class and can be obtained through the selective oxidation of betulin. In this study we set obtaining several functionalized derivatives of this compound by its condensation with several amino compounds such as aminoguanidine, hydroxylamine, n-butylamine and thiosemicarbazide as our goal. The functionalization of the parent compound led to several molecules with antiproliferative potential, the most promising being 3–2-carbamothioylhydrazonolup-20(29)-en-28-oic acid. |
| format | Online Article Text |
| id | pubmed-6332361 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-63323612019-01-24 Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives Ledeţi, Ionuţ Avram, Ştefana Bercean, Vasile Vlase, Gabriela Vlase, Titus Ledeţi, Adriana Zupko, Istvan Mioc, Marius Şuta, Lenuţa-Maria Şoica, Codruţa Dehelean, Cristina Molecules Article Betulonic acid belongs to the pentacyclic triterpenic derivative class and can be obtained through the selective oxidation of betulin. In this study we set obtaining several functionalized derivatives of this compound by its condensation with several amino compounds such as aminoguanidine, hydroxylamine, n-butylamine and thiosemicarbazide as our goal. The functionalization of the parent compound led to several molecules with antiproliferative potential, the most promising being 3–2-carbamothioylhydrazonolup-20(29)-en-28-oic acid. MDPI 2015-12-18 /pmc/articles/PMC6332361/ /pubmed/26694347 http://dx.doi.org/10.3390/molecules201219876 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Ledeţi, Ionuţ Avram, Ştefana Bercean, Vasile Vlase, Gabriela Vlase, Titus Ledeţi, Adriana Zupko, Istvan Mioc, Marius Şuta, Lenuţa-Maria Şoica, Codruţa Dehelean, Cristina Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives |
| title | Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives |
| title_full | Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives |
| title_fullStr | Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives |
| title_full_unstemmed | Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives |
| title_short | Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives |
| title_sort | solid-state characterization and biological activity of betulonic acid derivatives |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332361/ https://www.ncbi.nlm.nih.gov/pubmed/26694347 http://dx.doi.org/10.3390/molecules201219876 |
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