Synthesis, Fluorescence Properties, and Antiproliferative Potential of Several 3-Oxo-3H-benzo[f]chromene-2-carboxylic Acid Derivatives

In this study, two series of 3-oxo-3H-benzo[f]chromene-2-carboxylic acid derivatives (compounds 5a–i and 6a–g) were synthesized. Their in vitro proliferation inhibitory activities against the A549 and NCI-H460 human non-small cell lung cancer (NSCLC) cell lines were evaluated. Their photophysical pr...

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Autores principales: Fu, Xiao-Bo, Wang, Xian-Fu, Chen, Jia-Nian, Wu, De-Wen, Li, Ting, Shen, Xing-Can, Qin, Jiang-Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332379/
https://www.ncbi.nlm.nih.gov/pubmed/26473819
http://dx.doi.org/10.3390/molecules201018565
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author Fu, Xiao-Bo
Wang, Xian-Fu
Chen, Jia-Nian
Wu, De-Wen
Li, Ting
Shen, Xing-Can
Qin, Jiang-Ke
author_facet Fu, Xiao-Bo
Wang, Xian-Fu
Chen, Jia-Nian
Wu, De-Wen
Li, Ting
Shen, Xing-Can
Qin, Jiang-Ke
author_sort Fu, Xiao-Bo
collection PubMed
description In this study, two series of 3-oxo-3H-benzo[f]chromene-2-carboxylic acid derivatives (compounds 5a–i and 6a–g) were synthesized. Their in vitro proliferation inhibitory activities against the A549 and NCI-H460 human non-small cell lung cancer (NSCLC) cell lines were evaluated. Their photophysical properties were measured. Among these target compounds, 5e exhibited the strongest antiproliferative activity by inducing apoptosis, arresting cell cycle, and elevating intracellular reactive oxygen species (ROS) level, suggesting that it may be a potent antitumor agent. In addition, compound 6g with very low cytotoxicity, demonstrated excellent fluorescence properties, which could be used as an effective fluorescence probe for biological imaging.
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spelling pubmed-63323792019-01-24 Synthesis, Fluorescence Properties, and Antiproliferative Potential of Several 3-Oxo-3H-benzo[f]chromene-2-carboxylic Acid Derivatives Fu, Xiao-Bo Wang, Xian-Fu Chen, Jia-Nian Wu, De-Wen Li, Ting Shen, Xing-Can Qin, Jiang-Ke Molecules Article In this study, two series of 3-oxo-3H-benzo[f]chromene-2-carboxylic acid derivatives (compounds 5a–i and 6a–g) were synthesized. Their in vitro proliferation inhibitory activities against the A549 and NCI-H460 human non-small cell lung cancer (NSCLC) cell lines were evaluated. Their photophysical properties were measured. Among these target compounds, 5e exhibited the strongest antiproliferative activity by inducing apoptosis, arresting cell cycle, and elevating intracellular reactive oxygen species (ROS) level, suggesting that it may be a potent antitumor agent. In addition, compound 6g with very low cytotoxicity, demonstrated excellent fluorescence properties, which could be used as an effective fluorescence probe for biological imaging. MDPI 2015-10-13 /pmc/articles/PMC6332379/ /pubmed/26473819 http://dx.doi.org/10.3390/molecules201018565 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fu, Xiao-Bo
Wang, Xian-Fu
Chen, Jia-Nian
Wu, De-Wen
Li, Ting
Shen, Xing-Can
Qin, Jiang-Ke
Synthesis, Fluorescence Properties, and Antiproliferative Potential of Several 3-Oxo-3H-benzo[f]chromene-2-carboxylic Acid Derivatives
title Synthesis, Fluorescence Properties, and Antiproliferative Potential of Several 3-Oxo-3H-benzo[f]chromene-2-carboxylic Acid Derivatives
title_full Synthesis, Fluorescence Properties, and Antiproliferative Potential of Several 3-Oxo-3H-benzo[f]chromene-2-carboxylic Acid Derivatives
title_fullStr Synthesis, Fluorescence Properties, and Antiproliferative Potential of Several 3-Oxo-3H-benzo[f]chromene-2-carboxylic Acid Derivatives
title_full_unstemmed Synthesis, Fluorescence Properties, and Antiproliferative Potential of Several 3-Oxo-3H-benzo[f]chromene-2-carboxylic Acid Derivatives
title_short Synthesis, Fluorescence Properties, and Antiproliferative Potential of Several 3-Oxo-3H-benzo[f]chromene-2-carboxylic Acid Derivatives
title_sort synthesis, fluorescence properties, and antiproliferative potential of several 3-oxo-3h-benzo[f]chromene-2-carboxylic acid derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332379/
https://www.ncbi.nlm.nih.gov/pubmed/26473819
http://dx.doi.org/10.3390/molecules201018565
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