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A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models

The clinical efficacy of standardized essential oils (such as Lavender officinalis), in treating anxiety disorders strongly suggests that these natural products are an important candidate source for new anxiolytic drugs. A systematic review of essential oils, their bioactive constituents, and anxiol...

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Autores principales: de Sousa, Damião Pergentino, Soares Hocayen, Palloma de Almeida, Andrade, Luciana Nalone, Andreatini, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332383/
https://www.ncbi.nlm.nih.gov/pubmed/26473822
http://dx.doi.org/10.3390/molecules201018620
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author de Sousa, Damião Pergentino
Soares Hocayen, Palloma de Almeida
Andrade, Luciana Nalone
Andreatini, Roberto
author_facet de Sousa, Damião Pergentino
Soares Hocayen, Palloma de Almeida
Andrade, Luciana Nalone
Andreatini, Roberto
author_sort de Sousa, Damião Pergentino
collection PubMed
description The clinical efficacy of standardized essential oils (such as Lavender officinalis), in treating anxiety disorders strongly suggests that these natural products are an important candidate source for new anxiolytic drugs. A systematic review of essential oils, their bioactive constituents, and anxiolytic-like activity is conducted. The essential oil with the best profile is Lavendula angustifolia, which has already been tested in controlled clinical trials with positive results. Citrus aurantium using different routes of administration also showed significant effects in several animal models, and was corroborated by different research groups. Other promising essential oils are Citrus sinensis and bergamot oil, which showed certain clinical anxiolytic actions; along with Achillea wilhemsii, Alpinia zerumbet, Citrus aurantium, and Spiranthera odoratissima, which, like Lavendula angustifolia, appear to exert anxiolytic-like effects without GABA/benzodiazepine activity, thus differing in their mechanisms of action from the benzodiazepines. The anxiolytic activity of 25 compounds commonly found in essential oils is also discussed.
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spelling pubmed-63323832019-01-24 A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models de Sousa, Damião Pergentino Soares Hocayen, Palloma de Almeida Andrade, Luciana Nalone Andreatini, Roberto Molecules Review The clinical efficacy of standardized essential oils (such as Lavender officinalis), in treating anxiety disorders strongly suggests that these natural products are an important candidate source for new anxiolytic drugs. A systematic review of essential oils, their bioactive constituents, and anxiolytic-like activity is conducted. The essential oil with the best profile is Lavendula angustifolia, which has already been tested in controlled clinical trials with positive results. Citrus aurantium using different routes of administration also showed significant effects in several animal models, and was corroborated by different research groups. Other promising essential oils are Citrus sinensis and bergamot oil, which showed certain clinical anxiolytic actions; along with Achillea wilhemsii, Alpinia zerumbet, Citrus aurantium, and Spiranthera odoratissima, which, like Lavendula angustifolia, appear to exert anxiolytic-like effects without GABA/benzodiazepine activity, thus differing in their mechanisms of action from the benzodiazepines. The anxiolytic activity of 25 compounds commonly found in essential oils is also discussed. MDPI 2015-10-14 /pmc/articles/PMC6332383/ /pubmed/26473822 http://dx.doi.org/10.3390/molecules201018620 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
de Sousa, Damião Pergentino
Soares Hocayen, Palloma de Almeida
Andrade, Luciana Nalone
Andreatini, Roberto
A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models
title A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models
title_full A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models
title_fullStr A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models
title_full_unstemmed A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models
title_short A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models
title_sort systematic review of the anxiolytic-like effects of essential oils in animal models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332383/
https://www.ncbi.nlm.nih.gov/pubmed/26473822
http://dx.doi.org/10.3390/molecules201018620
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