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Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities
Ursolic acid (UA) is a natural terpene compound exhibiting many pharmaceutical properties. In this review the current state of knowledge about the health-promoting properties of this widespread, biologically active compound, as well as information about its occurrence and biosynthesis are presented....
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332387/ https://www.ncbi.nlm.nih.gov/pubmed/26610440 http://dx.doi.org/10.3390/molecules201119721 |
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author | Woźniak, Łukasz Skąpska, Sylwia Marszałek, Krystian |
author_facet | Woźniak, Łukasz Skąpska, Sylwia Marszałek, Krystian |
author_sort | Woźniak, Łukasz |
collection | PubMed |
description | Ursolic acid (UA) is a natural terpene compound exhibiting many pharmaceutical properties. In this review the current state of knowledge about the health-promoting properties of this widespread, biologically active compound, as well as information about its occurrence and biosynthesis are presented. Particular attention has been paid to the application of ursolic acid as an anti-cancer agent; it is worth noticing that clinical tests suggesting the possibility of practical use of UA have already been conducted. Amongst other pharmacological properties of UA one can mention protective effect on lungs, kidneys, liver and brain, anti-inflammatory properties, anabolic effects on skeletal muscles and the ability to suppress bone density loss leading to osteoporosis. Ursolic acid also exhibits anti-microbial features against numerous strains of bacteria, HIV and HCV viruses and Plasmodium protozoa causing malaria. |
format | Online Article Text |
id | pubmed-6332387 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63323872019-01-24 Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities Woźniak, Łukasz Skąpska, Sylwia Marszałek, Krystian Molecules Review Ursolic acid (UA) is a natural terpene compound exhibiting many pharmaceutical properties. In this review the current state of knowledge about the health-promoting properties of this widespread, biologically active compound, as well as information about its occurrence and biosynthesis are presented. Particular attention has been paid to the application of ursolic acid as an anti-cancer agent; it is worth noticing that clinical tests suggesting the possibility of practical use of UA have already been conducted. Amongst other pharmacological properties of UA one can mention protective effect on lungs, kidneys, liver and brain, anti-inflammatory properties, anabolic effects on skeletal muscles and the ability to suppress bone density loss leading to osteoporosis. Ursolic acid also exhibits anti-microbial features against numerous strains of bacteria, HIV and HCV viruses and Plasmodium protozoa causing malaria. MDPI 2015-11-19 /pmc/articles/PMC6332387/ /pubmed/26610440 http://dx.doi.org/10.3390/molecules201119721 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Woźniak, Łukasz Skąpska, Sylwia Marszałek, Krystian Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities |
title | Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities |
title_full | Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities |
title_fullStr | Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities |
title_full_unstemmed | Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities |
title_short | Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities |
title_sort | ursolic acid—a pentacyclic triterpenoid with a wide spectrum of pharmacological activities |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332387/ https://www.ncbi.nlm.nih.gov/pubmed/26610440 http://dx.doi.org/10.3390/molecules201119721 |
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