Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids

The antiproliferative activity of a set of seven natural Amaryllidaceae alkaloids and 32 derivatives against four cancer cell lines (A2780, SW1573, T47-D and WiDr) was determined. The best antiproliferative activities were achieved with alkaloids derived from pancracine (2), haemanthamine (6) and ha...

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Autores principales: Cedrón, Juan C., Ravelo, Ángel G., León, Leticia G., Padrón, José M., Estévez-Braun, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332398/
https://www.ncbi.nlm.nih.gov/pubmed/26263960
http://dx.doi.org/10.3390/molecules200813854
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author Cedrón, Juan C.
Ravelo, Ángel G.
León, Leticia G.
Padrón, José M.
Estévez-Braun, Ana
author_facet Cedrón, Juan C.
Ravelo, Ángel G.
León, Leticia G.
Padrón, José M.
Estévez-Braun, Ana
author_sort Cedrón, Juan C.
collection PubMed
description The antiproliferative activity of a set of seven natural Amaryllidaceae alkaloids and 32 derivatives against four cancer cell lines (A2780, SW1573, T47-D and WiDr) was determined. The best antiproliferative activities were achieved with alkaloids derived from pancracine (2), haemanthamine (6) and haemantidine (7). For each skeleton, some structure-activity relationships were outlined.
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spelling pubmed-63323982019-01-24 Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids Cedrón, Juan C. Ravelo, Ángel G. León, Leticia G. Padrón, José M. Estévez-Braun, Ana Molecules Article The antiproliferative activity of a set of seven natural Amaryllidaceae alkaloids and 32 derivatives against four cancer cell lines (A2780, SW1573, T47-D and WiDr) was determined. The best antiproliferative activities were achieved with alkaloids derived from pancracine (2), haemanthamine (6) and haemantidine (7). For each skeleton, some structure-activity relationships were outlined. MDPI 2015-07-30 /pmc/articles/PMC6332398/ /pubmed/26263960 http://dx.doi.org/10.3390/molecules200813854 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cedrón, Juan C.
Ravelo, Ángel G.
León, Leticia G.
Padrón, José M.
Estévez-Braun, Ana
Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids
title Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids
title_full Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids
title_fullStr Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids
title_full_unstemmed Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids
title_short Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids
title_sort antiproliferative and structure activity relationships of amaryllidaceae alkaloids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332398/
https://www.ncbi.nlm.nih.gov/pubmed/26263960
http://dx.doi.org/10.3390/molecules200813854
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