Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad

Two new tetracyclic cucurbitane-type triterpene glycosides were isolated from an ethyl acetate extract of Citrullus colocynthis leaves together with four known cucurbitacins. Their structures were established on the basis of their spectroscopic data (mainly NMR and mass spectrometry). Evaluation of...

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Detalles Bibliográficos
Autores principales: Chawech, Rachid, Jarraya, Raoudha, Girardi, Cynthia, Vansteelandt, Marieke, Marti, Guillaume, Nasri, Imen, Racaud-Sultan, Claire, Fabre, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332406/
https://www.ncbi.nlm.nih.gov/pubmed/26437392
http://dx.doi.org/10.3390/molecules201018001
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author Chawech, Rachid
Jarraya, Raoudha
Girardi, Cynthia
Vansteelandt, Marieke
Marti, Guillaume
Nasri, Imen
Racaud-Sultan, Claire
Fabre, Nicolas
author_facet Chawech, Rachid
Jarraya, Raoudha
Girardi, Cynthia
Vansteelandt, Marieke
Marti, Guillaume
Nasri, Imen
Racaud-Sultan, Claire
Fabre, Nicolas
author_sort Chawech, Rachid
collection PubMed
description Two new tetracyclic cucurbitane-type triterpene glycosides were isolated from an ethyl acetate extract of Citrullus colocynthis leaves together with four known cucurbitacins. Their structures were established on the basis of their spectroscopic data (mainly NMR and mass spectrometry). Evaluation of the in vitro cytotoxic activity of the isolated compounds against two human colon cancer cell lines (HT29 and Caco-2) and one normal rat intestine epithelial cell line (IEC6), revealed that one of the isolated compounds presented interesting specific cytotoxic activity towards colorectal cell lines.
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spelling pubmed-63324062019-01-24 Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad Chawech, Rachid Jarraya, Raoudha Girardi, Cynthia Vansteelandt, Marieke Marti, Guillaume Nasri, Imen Racaud-Sultan, Claire Fabre, Nicolas Molecules Article Two new tetracyclic cucurbitane-type triterpene glycosides were isolated from an ethyl acetate extract of Citrullus colocynthis leaves together with four known cucurbitacins. Their structures were established on the basis of their spectroscopic data (mainly NMR and mass spectrometry). Evaluation of the in vitro cytotoxic activity of the isolated compounds against two human colon cancer cell lines (HT29 and Caco-2) and one normal rat intestine epithelial cell line (IEC6), revealed that one of the isolated compounds presented interesting specific cytotoxic activity towards colorectal cell lines. MDPI 2015-09-30 /pmc/articles/PMC6332406/ /pubmed/26437392 http://dx.doi.org/10.3390/molecules201018001 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chawech, Rachid
Jarraya, Raoudha
Girardi, Cynthia
Vansteelandt, Marieke
Marti, Guillaume
Nasri, Imen
Racaud-Sultan, Claire
Fabre, Nicolas
Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad
title Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad
title_full Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad
title_fullStr Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad
title_full_unstemmed Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad
title_short Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad
title_sort cucurbitacins from the leaves of citrullus colocynthis (l.) schrad
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332406/
https://www.ncbi.nlm.nih.gov/pubmed/26437392
http://dx.doi.org/10.3390/molecules201018001
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