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Design, Synthesis and Biological Evaluation of Novel Substituted N,N′-Diaryl ureas as Potent p38 Inhibitors

A novel series of substituted N,N′-diaryl ureas that act as p38α inhibitors have been designed and synthesized based on two key residues (Gly110 and Thr106) that are different in p38α MAPK than in other kinases. Preliminary biological evaluation indicated that most compounds possessed good p38α inhi...

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Detalles Bibliográficos
Autores principales:	Zhu, Dianxi, Li, Xingzhou, Zhong, Wu, Zhao, Dongmei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332430/ https://www.ncbi.nlm.nih.gov/pubmed/26378516 http://dx.doi.org/10.3390/molecules200916604

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