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SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model
[Image: see text] The clinical effectiveness of carbapenem antibiotics such as meropenem is becoming increasingly compromised by the spread of both metallo-β-lactamase (MBL) and serine-β-lactamase (SBL) enzymes on mobile genetic elements, stimulating research to find new β-lactamase inhibitors to be...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332448/ https://www.ncbi.nlm.nih.gov/pubmed/30427656 http://dx.doi.org/10.1021/acsinfecdis.8b00246 |
| _version_ | 1783387353195216896 |
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| author | Leiris, Simon Coelho, Alicia Castandet, Jérôme Bayet, Maëlle Lozano, Clarisse Bougnon, Juliette Bousquet, Justine Everett, Martin Lemonnier, Marc Sprynski, Nicolas Zalacain, Magdalena Pallin, Thomas David Cramp, Michael C. Jennings, Neil Raphy, Gilles Jones, Mark W. Pattipati, Ramesh Shankar, Battu Sivasubrahmanyam, Relangi Soodhagani, Ashok K. Juventhala, Ramakrishna R. Pottabathini, Narender Pothukanuri, Srinivasu Benvenuti, Manuela Pozzi, Cecilia Mangani, Stefano De Luca, Filomena Cerboni, Giulia Docquier, Jean-Denis Davies, David T. |
| author_facet | Leiris, Simon Coelho, Alicia Castandet, Jérôme Bayet, Maëlle Lozano, Clarisse Bougnon, Juliette Bousquet, Justine Everett, Martin Lemonnier, Marc Sprynski, Nicolas Zalacain, Magdalena Pallin, Thomas David Cramp, Michael C. Jennings, Neil Raphy, Gilles Jones, Mark W. Pattipati, Ramesh Shankar, Battu Sivasubrahmanyam, Relangi Soodhagani, Ashok K. Juventhala, Ramakrishna R. Pottabathini, Narender Pothukanuri, Srinivasu Benvenuti, Manuela Pozzi, Cecilia Mangani, Stefano De Luca, Filomena Cerboni, Giulia Docquier, Jean-Denis Davies, David T. |
| author_sort | Leiris, Simon |
| collection | PubMed |
| description | [Image: see text] The clinical effectiveness of carbapenem antibiotics such as meropenem is becoming increasingly compromised by the spread of both metallo-β-lactamase (MBL) and serine-β-lactamase (SBL) enzymes on mobile genetic elements, stimulating research to find new β-lactamase inhibitors to be used in conjunction with carbapenems and other β-lactam antibiotics. Herein, we describe our initial exploration of a novel chemical series of metallo-β-lactamase inhibitors, from concept to efficacy, in a survival model using an advanced tool compound (ANT431) in conjunction with meropenem. |
| format | Online Article Text |
| id | pubmed-6332448 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | American Chemical
Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-63324482019-01-17 SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model Leiris, Simon Coelho, Alicia Castandet, Jérôme Bayet, Maëlle Lozano, Clarisse Bougnon, Juliette Bousquet, Justine Everett, Martin Lemonnier, Marc Sprynski, Nicolas Zalacain, Magdalena Pallin, Thomas David Cramp, Michael C. Jennings, Neil Raphy, Gilles Jones, Mark W. Pattipati, Ramesh Shankar, Battu Sivasubrahmanyam, Relangi Soodhagani, Ashok K. Juventhala, Ramakrishna R. Pottabathini, Narender Pothukanuri, Srinivasu Benvenuti, Manuela Pozzi, Cecilia Mangani, Stefano De Luca, Filomena Cerboni, Giulia Docquier, Jean-Denis Davies, David T. ACS Infect Dis [Image: see text] The clinical effectiveness of carbapenem antibiotics such as meropenem is becoming increasingly compromised by the spread of both metallo-β-lactamase (MBL) and serine-β-lactamase (SBL) enzymes on mobile genetic elements, stimulating research to find new β-lactamase inhibitors to be used in conjunction with carbapenems and other β-lactam antibiotics. Herein, we describe our initial exploration of a novel chemical series of metallo-β-lactamase inhibitors, from concept to efficacy, in a survival model using an advanced tool compound (ANT431) in conjunction with meropenem. American Chemical Society 2018-11-14 2019-01-11 /pmc/articles/PMC6332448/ /pubmed/30427656 http://dx.doi.org/10.1021/acsinfecdis.8b00246 Text en Copyright © 2018 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. |
| spellingShingle | Leiris, Simon Coelho, Alicia Castandet, Jérôme Bayet, Maëlle Lozano, Clarisse Bougnon, Juliette Bousquet, Justine Everett, Martin Lemonnier, Marc Sprynski, Nicolas Zalacain, Magdalena Pallin, Thomas David Cramp, Michael C. Jennings, Neil Raphy, Gilles Jones, Mark W. Pattipati, Ramesh Shankar, Battu Sivasubrahmanyam, Relangi Soodhagani, Ashok K. Juventhala, Ramakrishna R. Pottabathini, Narender Pothukanuri, Srinivasu Benvenuti, Manuela Pozzi, Cecilia Mangani, Stefano De Luca, Filomena Cerboni, Giulia Docquier, Jean-Denis Davies, David T. SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model |
| title | SAR Studies Leading to the Identification of a Novel
Series of Metallo-β-lactamase Inhibitors for the Treatment of
Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy
in an Animal Infection Model |
| title_full | SAR Studies Leading to the Identification of a Novel
Series of Metallo-β-lactamase Inhibitors for the Treatment of
Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy
in an Animal Infection Model |
| title_fullStr | SAR Studies Leading to the Identification of a Novel
Series of Metallo-β-lactamase Inhibitors for the Treatment of
Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy
in an Animal Infection Model |
| title_full_unstemmed | SAR Studies Leading to the Identification of a Novel
Series of Metallo-β-lactamase Inhibitors for the Treatment of
Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy
in an Animal Infection Model |
| title_short | SAR Studies Leading to the Identification of a Novel
Series of Metallo-β-lactamase Inhibitors for the Treatment of
Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy
in an Animal Infection Model |
| title_sort | sar studies leading to the identification of a novel
series of metallo-β-lactamase inhibitors for the treatment of
carbapenem-resistant enterobacteriaceae infections that display efficacy
in an animal infection model |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332448/ https://www.ncbi.nlm.nih.gov/pubmed/30427656 http://dx.doi.org/10.1021/acsinfecdis.8b00246 |
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