SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model

[Image: see text] The clinical effectiveness of carbapenem antibiotics such as meropenem is becoming increasingly compromised by the spread of both metallo-β-lactamase (MBL) and serine-β-lactamase (SBL) enzymes on mobile genetic elements, stimulating research to find new β-lactamase inhibitors to be...

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Detalles Bibliográficos
Autores principales: Leiris, Simon, Coelho, Alicia, Castandet, Jérôme, Bayet, Maëlle, Lozano, Clarisse, Bougnon, Juliette, Bousquet, Justine, Everett, Martin, Lemonnier, Marc, Sprynski, Nicolas, Zalacain, Magdalena, Pallin, Thomas David, Cramp, Michael C., Jennings, Neil, Raphy, Gilles, Jones, Mark W., Pattipati, Ramesh, Shankar, Battu, Sivasubrahmanyam, Relangi, Soodhagani, Ashok K., Juventhala, Ramakrishna R., Pottabathini, Narender, Pothukanuri, Srinivasu, Benvenuti, Manuela, Pozzi, Cecilia, Mangani, Stefano, De Luca, Filomena, Cerboni, Giulia, Docquier, Jean-Denis, Davies, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332448/
https://www.ncbi.nlm.nih.gov/pubmed/30427656
http://dx.doi.org/10.1021/acsinfecdis.8b00246

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