Asymmetric Synthesis of 1,3-Oxazolidine Derivatives with Multi-Component Reaction and Research of Kinetic Resolution

An efficient multi-component reaction to synthesize multi-substituted 1,3-oxazolidine compounds of high optical purity was described. All the products were well-characterized and the absolute configuration of one chiral center was determined. The plausible mechanism was proposed and a kinetic resolu...

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Detalles Bibliográficos
Autores principales: Hong, Xiao-Wei, Zhou, Yu-Qiang, Bai, Cui-Bing, Wang, Nai-Xing, Xing, Yalan, Zhang, Wei, Wang, Yan-Jing, Lan, Xing-Wang, Xie, Yu, Li, Yi-He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332461/
https://www.ncbi.nlm.nih.gov/pubmed/26393558
http://dx.doi.org/10.3390/molecules200917208
Descripción
Sumario:An efficient multi-component reaction to synthesize multi-substituted 1,3-oxazolidine compounds of high optical purity was described. All the products were well-characterized and the absolute configuration of one chiral center was determined. The plausible mechanism was proposed and a kinetic resolution of epoxides process was confirmed.

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