Asymmetric Synthesis of 1,3-Oxazolidine Derivatives with Multi-Component Reaction and Research of Kinetic Resolution

An efficient multi-component reaction to synthesize multi-substituted 1,3-oxazolidine compounds of high optical purity was described. All the products were well-characterized and the absolute configuration of one chiral center was determined. The plausible mechanism was proposed and a kinetic resolu...

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Autores principales: Hong, Xiao-Wei, Zhou, Yu-Qiang, Bai, Cui-Bing, Wang, Nai-Xing, Xing, Yalan, Zhang, Wei, Wang, Yan-Jing, Lan, Xing-Wang, Xie, Yu, Li, Yi-He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332461/
https://www.ncbi.nlm.nih.gov/pubmed/26393558
http://dx.doi.org/10.3390/molecules200917208
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author Hong, Xiao-Wei
Zhou, Yu-Qiang
Bai, Cui-Bing
Wang, Nai-Xing
Xing, Yalan
Zhang, Wei
Wang, Yan-Jing
Lan, Xing-Wang
Xie, Yu
Li, Yi-He
author_facet Hong, Xiao-Wei
Zhou, Yu-Qiang
Bai, Cui-Bing
Wang, Nai-Xing
Xing, Yalan
Zhang, Wei
Wang, Yan-Jing
Lan, Xing-Wang
Xie, Yu
Li, Yi-He
author_sort Hong, Xiao-Wei
collection PubMed
description An efficient multi-component reaction to synthesize multi-substituted 1,3-oxazolidine compounds of high optical purity was described. All the products were well-characterized and the absolute configuration of one chiral center was determined. The plausible mechanism was proposed and a kinetic resolution of epoxides process was confirmed.
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spelling pubmed-63324612019-01-24 Asymmetric Synthesis of 1,3-Oxazolidine Derivatives with Multi-Component Reaction and Research of Kinetic Resolution Hong, Xiao-Wei Zhou, Yu-Qiang Bai, Cui-Bing Wang, Nai-Xing Xing, Yalan Zhang, Wei Wang, Yan-Jing Lan, Xing-Wang Xie, Yu Li, Yi-He Molecules Article An efficient multi-component reaction to synthesize multi-substituted 1,3-oxazolidine compounds of high optical purity was described. All the products were well-characterized and the absolute configuration of one chiral center was determined. The plausible mechanism was proposed and a kinetic resolution of epoxides process was confirmed. MDPI 2015-09-18 /pmc/articles/PMC6332461/ /pubmed/26393558 http://dx.doi.org/10.3390/molecules200917208 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hong, Xiao-Wei
Zhou, Yu-Qiang
Bai, Cui-Bing
Wang, Nai-Xing
Xing, Yalan
Zhang, Wei
Wang, Yan-Jing
Lan, Xing-Wang
Xie, Yu
Li, Yi-He
Asymmetric Synthesis of 1,3-Oxazolidine Derivatives with Multi-Component Reaction and Research of Kinetic Resolution
title Asymmetric Synthesis of 1,3-Oxazolidine Derivatives with Multi-Component Reaction and Research of Kinetic Resolution
title_full Asymmetric Synthesis of 1,3-Oxazolidine Derivatives with Multi-Component Reaction and Research of Kinetic Resolution
title_fullStr Asymmetric Synthesis of 1,3-Oxazolidine Derivatives with Multi-Component Reaction and Research of Kinetic Resolution
title_full_unstemmed Asymmetric Synthesis of 1,3-Oxazolidine Derivatives with Multi-Component Reaction and Research of Kinetic Resolution
title_short Asymmetric Synthesis of 1,3-Oxazolidine Derivatives with Multi-Component Reaction and Research of Kinetic Resolution
title_sort asymmetric synthesis of 1,3-oxazolidine derivatives with multi-component reaction and research of kinetic resolution
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332461/
https://www.ncbi.nlm.nih.gov/pubmed/26393558
http://dx.doi.org/10.3390/molecules200917208
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