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Antibacterial and Antitumor Activities of Biscoumarin and Dihydropyran Derivatives
A novel series of biscoumarin (1–4) and dihydropyran (5–13) derivatives were synthesized via a one-pot multicomponent condensation reaction and evaluated for antibacterial and antitumor activity in vitro. The X-ray crystal structure analysis of four representative compounds, 3, 7, 9 and 11, confirme...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332513/ https://www.ncbi.nlm.nih.gov/pubmed/26404230 http://dx.doi.org/10.3390/molecules200917614 |
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author | Sui, Yun-Peng Huo, Hai-Ru Xin, Jia-Jia Li, Jing Li, Xiao-Jun Du, Xin-Liang Ma, Hai Zhou, Hai-Yu Zhan, Hong-Dan Wang, Zhu-Ju Li, Chun Sui, Feng Li, Ming-Kai |
author_facet | Sui, Yun-Peng Huo, Hai-Ru Xin, Jia-Jia Li, Jing Li, Xiao-Jun Du, Xin-Liang Ma, Hai Zhou, Hai-Yu Zhan, Hong-Dan Wang, Zhu-Ju Li, Chun Sui, Feng Li, Ming-Kai |
author_sort | Sui, Yun-Peng |
collection | PubMed |
description | A novel series of biscoumarin (1–4) and dihydropyran (5–13) derivatives were synthesized via a one-pot multicomponent condensation reaction and evaluated for antibacterial and antitumor activity in vitro. The X-ray crystal structure analysis of four representative compounds, 3, 7, 9 and 11, confirmed the structures of these compounds. Compounds 1–4 showed the most potent antitumor activity among the total 13 derivatives; especially for compounds 1 and 2, they also emerged as promising antibacterial members with better antibacterial activity. In addition, the results of density functional theory (DFT) showed that compared with compounds 3 and 4, biscoumarins 1 and 2 had lower intramolecular hydrogen bonds (HB) energy in their structures. |
format | Online Article Text |
id | pubmed-6332513 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63325132019-01-24 Antibacterial and Antitumor Activities of Biscoumarin and Dihydropyran Derivatives Sui, Yun-Peng Huo, Hai-Ru Xin, Jia-Jia Li, Jing Li, Xiao-Jun Du, Xin-Liang Ma, Hai Zhou, Hai-Yu Zhan, Hong-Dan Wang, Zhu-Ju Li, Chun Sui, Feng Li, Ming-Kai Molecules Article A novel series of biscoumarin (1–4) and dihydropyran (5–13) derivatives were synthesized via a one-pot multicomponent condensation reaction and evaluated for antibacterial and antitumor activity in vitro. The X-ray crystal structure analysis of four representative compounds, 3, 7, 9 and 11, confirmed the structures of these compounds. Compounds 1–4 showed the most potent antitumor activity among the total 13 derivatives; especially for compounds 1 and 2, they also emerged as promising antibacterial members with better antibacterial activity. In addition, the results of density functional theory (DFT) showed that compared with compounds 3 and 4, biscoumarins 1 and 2 had lower intramolecular hydrogen bonds (HB) energy in their structures. MDPI 2015-09-23 /pmc/articles/PMC6332513/ /pubmed/26404230 http://dx.doi.org/10.3390/molecules200917614 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sui, Yun-Peng Huo, Hai-Ru Xin, Jia-Jia Li, Jing Li, Xiao-Jun Du, Xin-Liang Ma, Hai Zhou, Hai-Yu Zhan, Hong-Dan Wang, Zhu-Ju Li, Chun Sui, Feng Li, Ming-Kai Antibacterial and Antitumor Activities of Biscoumarin and Dihydropyran Derivatives |
title | Antibacterial and Antitumor Activities of Biscoumarin and Dihydropyran Derivatives |
title_full | Antibacterial and Antitumor Activities of Biscoumarin and Dihydropyran Derivatives |
title_fullStr | Antibacterial and Antitumor Activities of Biscoumarin and Dihydropyran Derivatives |
title_full_unstemmed | Antibacterial and Antitumor Activities of Biscoumarin and Dihydropyran Derivatives |
title_short | Antibacterial and Antitumor Activities of Biscoumarin and Dihydropyran Derivatives |
title_sort | antibacterial and antitumor activities of biscoumarin and dihydropyran derivatives |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332513/ https://www.ncbi.nlm.nih.gov/pubmed/26404230 http://dx.doi.org/10.3390/molecules200917614 |
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