Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia

BACKGROUND: Streptococcus pneumoniae is a major causative agent in community-acquired pneumonia and sepsis. Overwhelming lung inflammation during pneumococcal pneumonia may hamper lung function. Ibrutinib is an irreversible inhibitor of Bruton’s tyrosine kinase (Btk), a key signaling protein control...

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Detalles Bibliográficos
Autores principales: de Porto, Alexander P., Liu, Zhe, de Beer, Regina, Florquin, Sandrine, de Boer, Onno J., Hendriks, Rudi W., van der Poll, Tom, de Vos, Alex F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332549/
https://www.ncbi.nlm.nih.gov/pubmed/30646846
http://dx.doi.org/10.1186/s10020-018-0069-7

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