Comparing the EQ-5D-5L utility index based on value sets of different countries: impact on the interpretation of clinical study results

OBJECTIVE: To compare the country-specific value sets of the EQ-5D-5L utility index and to evaluate the impact on the interpretation of clinical study results. Six country value sets from Canada, England, Japan, Korea, Netherlands and Uruguay were obtained from literature. In addition, ten crosswalk...

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Autores principales: Gerlinger, Christoph, Bamber, Luke, Leverkus, Friedhelm, Schwenke, Carsten, Haberland, Claudia, Schmidt, Gilda, Endrikat, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332559/
https://www.ncbi.nlm.nih.gov/pubmed/30642397
http://dx.doi.org/10.1186/s13104-019-4067-9
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author Gerlinger, Christoph
Bamber, Luke
Leverkus, Friedhelm
Schwenke, Carsten
Haberland, Claudia
Schmidt, Gilda
Endrikat, Jan
author_facet Gerlinger, Christoph
Bamber, Luke
Leverkus, Friedhelm
Schwenke, Carsten
Haberland, Claudia
Schmidt, Gilda
Endrikat, Jan
author_sort Gerlinger, Christoph
collection PubMed
description OBJECTIVE: To compare the country-specific value sets of the EQ-5D-5L utility index and to evaluate the impact on the interpretation of clinical study results. Six country value sets from Canada, England, Japan, Korea, Netherlands and Uruguay were obtained from literature. In addition, ten crosswalk value sets were downloaded from the EuroQol.org website. RESULTS: For each of the 3125 possible health states the difference between the country with the highest index and the country with the lowest index was calculated. The median difference was 0.417 across the health states. When analyzing multinational clinical studies, country-specific value sets should be used to evaluate treatment effects. Additional country-specific analyses are needed. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-019-4067-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-63325592019-01-16 Comparing the EQ-5D-5L utility index based on value sets of different countries: impact on the interpretation of clinical study results Gerlinger, Christoph Bamber, Luke Leverkus, Friedhelm Schwenke, Carsten Haberland, Claudia Schmidt, Gilda Endrikat, Jan BMC Res Notes Research Note OBJECTIVE: To compare the country-specific value sets of the EQ-5D-5L utility index and to evaluate the impact on the interpretation of clinical study results. Six country value sets from Canada, England, Japan, Korea, Netherlands and Uruguay were obtained from literature. In addition, ten crosswalk value sets were downloaded from the EuroQol.org website. RESULTS: For each of the 3125 possible health states the difference between the country with the highest index and the country with the lowest index was calculated. The median difference was 0.417 across the health states. When analyzing multinational clinical studies, country-specific value sets should be used to evaluate treatment effects. Additional country-specific analyses are needed. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-019-4067-9) contains supplementary material, which is available to authorized users. BioMed Central 2019-01-14 /pmc/articles/PMC6332559/ /pubmed/30642397 http://dx.doi.org/10.1186/s13104-019-4067-9 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Gerlinger, Christoph
Bamber, Luke
Leverkus, Friedhelm
Schwenke, Carsten
Haberland, Claudia
Schmidt, Gilda
Endrikat, Jan
Comparing the EQ-5D-5L utility index based on value sets of different countries: impact on the interpretation of clinical study results
title Comparing the EQ-5D-5L utility index based on value sets of different countries: impact on the interpretation of clinical study results
title_full Comparing the EQ-5D-5L utility index based on value sets of different countries: impact on the interpretation of clinical study results
title_fullStr Comparing the EQ-5D-5L utility index based on value sets of different countries: impact on the interpretation of clinical study results
title_full_unstemmed Comparing the EQ-5D-5L utility index based on value sets of different countries: impact on the interpretation of clinical study results
title_short Comparing the EQ-5D-5L utility index based on value sets of different countries: impact on the interpretation of clinical study results
title_sort comparing the eq-5d-5l utility index based on value sets of different countries: impact on the interpretation of clinical study results
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332559/
https://www.ncbi.nlm.nih.gov/pubmed/30642397
http://dx.doi.org/10.1186/s13104-019-4067-9
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