Cargando…
Dosage sensitivity of X-linked genes in human embryonic single cells
BACKGROUND: During the evolution of mammalian sex chromosomes, the degeneration of Y-linked homologs has led to a dosage imbalance between X-linked and autosomal genes. The evolutionary resolution to such dosage imbalance, as hypothesized by Susumu Ohno fifty years ago, should be doubling the expres...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332578/ https://www.ncbi.nlm.nih.gov/pubmed/30642250 http://dx.doi.org/10.1186/s12864-019-5432-8 |