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Context-dependent roles of MDMX (MDM4) and MDM2 in breast cancer proliferation and circulating tumor cells

INTRODUCTION: Many human breast cancers overexpress the E3 ubiquitin ligase MDM2 and its homolog MDMX. Expression of MDM2 and MDMX occurs in estrogen receptor α-positive (ERα(+)) breast cancer and triple-negative breast cancer (TNBC). There are p53-independent influences of MDM2 and MDMX, and 80% of...

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Detalles Bibliográficos
Autores principales:	Gao, Chong, Xiao, Gu, Piersigilli, Alessandra, Gou, Jiangtao, Ogunwobi, Olorunseun, Bargonetti, Jill
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332579/ https://www.ncbi.nlm.nih.gov/pubmed/30642351 http://dx.doi.org/10.1186/s13058-018-1094-8

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