Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia

Levodopa-induced dyskinesias (LID) are a prevalent side effect of chronic treatment with levodopa (L-DOPA) for the motor symptoms of Parkinson’s disease (PD). It has long been hypothesized that serotonergic neurons of the dorsal raphe nucleus (DRN) are capable of L-DOPA uptake and dysregulated relea...

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Detalles Bibliográficos
Autores principales: Sellnow, Rhyomi C., Newman, Jordan H., Chambers, Nicole, West, Anthony R., Steece-Collier, Kathy, Sandoval, Ivette M., Benskey, Matthew J., Bishop, Christopher, Manfredsson, Fredric P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332643/
https://www.ncbi.nlm.nih.gov/pubmed/30646956
http://dx.doi.org/10.1186/s40478-018-0653-7

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