Whole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and TNXB genes

BACKGROUND: Age-related macular degeneration (AMD) is a degenerative disorder of the central retina and the foremost cause of blindness. The retinal pigment epithelium (RPE) is a primary site of disease pathogenesis. The genetic basis of AMD is relatively well understood; however, this knowledge is...

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Detalles Bibliográficos
Autores principales: Porter, Louise F., Saptarshi, Neil, Fang, Yongxiang, Rathi, Sonika, den Hollander, Anneke I., de Jong, Eiko K., Clark, Simon J., Bishop, Paul N., Olsen, Timothy W., Liloglou, Triantafillos, Chavali, Venkata R. M., Paraoan, Luminita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332695/
https://www.ncbi.nlm.nih.gov/pubmed/30642396
http://dx.doi.org/10.1186/s13148-019-0608-2

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