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AMYCO: evaluation of mutational impact on prion-like proteins aggregation propensity
BACKGROUND: Around 1% of human proteins are predicted to contain a disordered and low complexity prion-like domain (PrLD). Mutations in PrLDs have been shown promote a transition towards an aggregation-prone state in several diseases. RESULTS: Recently, we have shown that an algorithm that considers...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332698/ https://www.ncbi.nlm.nih.gov/pubmed/30642249 http://dx.doi.org/10.1186/s12859-019-2601-3 |