Targeting lipid metabolism to overcome EMT-associated drug resistance via integrin β3/FAK pathway and tumor-associated macrophage repolarization using legumain-activatable delivery

Epithelial-mesenchymal transition (EMT) is closely associated with the development of drug resistance. Lipid metabolism plays an important role in EMT. This work was to study the cholesterol-lowering drug simvastatin for reversing EMT-associated resistance to chemotherapy via lipid metabolism. Metho...

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Detalles Bibliográficos
Autores principales: Jin, Hongyue, He, Yang, Zhao, Pengfei, Hu, Ying, Tao, Jin, Chen, Jiang, Huang, Yongzhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332796/
https://www.ncbi.nlm.nih.gov/pubmed/30662566
http://dx.doi.org/10.7150/thno.27246

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