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Efficacy of the combination use of aprepitant and palonosetron for improving nausea in various moderately emetogenic chemotherapy regimens

BACKGROUND: Nausea is more difficult to control than vomiting in chemotherapy. We therefore analyzed the efficacy of a strong supportive treatment with aprepitant, palonosetron, and dexamethasone against nausea for various moderately emetogenic chemotherapy (MEC). METHODS: A total of 312 cases treat...

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Autores principales: Yoshida, Naohisa, Taguchi, Tetsuya, Nakanishi, Masayoshi, Inoue, Ken, Okayama, Tetsuya, Ishikawa, Takeshi, Otsuji, Eigo, Takayama, Koichi, Kuroboshi, Haruo, Kanazawa, Motohiro, Itoh, Yoshito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332848/
https://www.ncbi.nlm.nih.gov/pubmed/30642399
http://dx.doi.org/10.1186/s40360-018-0278-2
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author Yoshida, Naohisa
Taguchi, Tetsuya
Nakanishi, Masayoshi
Inoue, Ken
Okayama, Tetsuya
Ishikawa, Takeshi
Otsuji, Eigo
Takayama, Koichi
Kuroboshi, Haruo
Kanazawa, Motohiro
Itoh, Yoshito
author_facet Yoshida, Naohisa
Taguchi, Tetsuya
Nakanishi, Masayoshi
Inoue, Ken
Okayama, Tetsuya
Ishikawa, Takeshi
Otsuji, Eigo
Takayama, Koichi
Kuroboshi, Haruo
Kanazawa, Motohiro
Itoh, Yoshito
author_sort Yoshida, Naohisa
collection PubMed
description BACKGROUND: Nausea is more difficult to control than vomiting in chemotherapy. We therefore analyzed the efficacy of a strong supportive treatment with aprepitant, palonosetron, and dexamethasone against nausea for various moderately emetogenic chemotherapy (MEC). METHODS: A total of 312 cases treated by palonosetron with or without aprepitant receiving MEC regimens using oxaliplatin, carboplatin, and irinotecan from 2014 to 2016 in our outpatient center for digestive organ cancers, lung cancers, and gynecological cancers were analyzed. Through propensity score matching analysis, cases were divided into 97 cases receiving 2 drugs (palonosetron+dexamethasone) and 97 receiving 3 drugs (aprepitant+palonosetron+dexamethasone). We examined the control rates of nausea for the first two consecutive courses in the both groups. Additionally, risk factors for acute and delayed nausea were analyzed using a multivariate analysis among overall 312 cases. RESULTS: The control rates of nausea in the two- and the three-drug groups were as follows: acute, 92.8 and 95.9% (p = 0.35); and delayed, 83.5 and 81.4% (p = 0.85), although the control rates of vomiting exceeded 95% in both groups. A multivariate analysis showed that significant risk factors for acute nausea (odds ratio, 95% confidence interval) were elevation of serum creatinine (12.601, 2.437–65.157), general fatigue (3.728, 1.098–12.661), and performance status (PS) 2 (19.829, 3.200–122.865). The significant risk factors for delayed nausea were elevation of alanine aminotransferase (2.397, 1.153–4.984), general fatigue (2.652, 1.380–5.097), and PS 2 (5.748, 1.392–23.740). CONCLUSIONS: The control for nausea in MEC was insufficient even with palonosetron and aprepitant, and we should pay attention to risk factors for preventing nausea.
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spelling pubmed-63328482019-01-23 Efficacy of the combination use of aprepitant and palonosetron for improving nausea in various moderately emetogenic chemotherapy regimens Yoshida, Naohisa Taguchi, Tetsuya Nakanishi, Masayoshi Inoue, Ken Okayama, Tetsuya Ishikawa, Takeshi Otsuji, Eigo Takayama, Koichi Kuroboshi, Haruo Kanazawa, Motohiro Itoh, Yoshito BMC Pharmacol Toxicol Research Article BACKGROUND: Nausea is more difficult to control than vomiting in chemotherapy. We therefore analyzed the efficacy of a strong supportive treatment with aprepitant, palonosetron, and dexamethasone against nausea for various moderately emetogenic chemotherapy (MEC). METHODS: A total of 312 cases treated by palonosetron with or without aprepitant receiving MEC regimens using oxaliplatin, carboplatin, and irinotecan from 2014 to 2016 in our outpatient center for digestive organ cancers, lung cancers, and gynecological cancers were analyzed. Through propensity score matching analysis, cases were divided into 97 cases receiving 2 drugs (palonosetron+dexamethasone) and 97 receiving 3 drugs (aprepitant+palonosetron+dexamethasone). We examined the control rates of nausea for the first two consecutive courses in the both groups. Additionally, risk factors for acute and delayed nausea were analyzed using a multivariate analysis among overall 312 cases. RESULTS: The control rates of nausea in the two- and the three-drug groups were as follows: acute, 92.8 and 95.9% (p = 0.35); and delayed, 83.5 and 81.4% (p = 0.85), although the control rates of vomiting exceeded 95% in both groups. A multivariate analysis showed that significant risk factors for acute nausea (odds ratio, 95% confidence interval) were elevation of serum creatinine (12.601, 2.437–65.157), general fatigue (3.728, 1.098–12.661), and performance status (PS) 2 (19.829, 3.200–122.865). The significant risk factors for delayed nausea were elevation of alanine aminotransferase (2.397, 1.153–4.984), general fatigue (2.652, 1.380–5.097), and PS 2 (5.748, 1.392–23.740). CONCLUSIONS: The control for nausea in MEC was insufficient even with palonosetron and aprepitant, and we should pay attention to risk factors for preventing nausea. BioMed Central 2019-01-14 /pmc/articles/PMC6332848/ /pubmed/30642399 http://dx.doi.org/10.1186/s40360-018-0278-2 Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Yoshida, Naohisa
Taguchi, Tetsuya
Nakanishi, Masayoshi
Inoue, Ken
Okayama, Tetsuya
Ishikawa, Takeshi
Otsuji, Eigo
Takayama, Koichi
Kuroboshi, Haruo
Kanazawa, Motohiro
Itoh, Yoshito
Efficacy of the combination use of aprepitant and palonosetron for improving nausea in various moderately emetogenic chemotherapy regimens
title Efficacy of the combination use of aprepitant and palonosetron for improving nausea in various moderately emetogenic chemotherapy regimens
title_full Efficacy of the combination use of aprepitant and palonosetron for improving nausea in various moderately emetogenic chemotherapy regimens
title_fullStr Efficacy of the combination use of aprepitant and palonosetron for improving nausea in various moderately emetogenic chemotherapy regimens
title_full_unstemmed Efficacy of the combination use of aprepitant and palonosetron for improving nausea in various moderately emetogenic chemotherapy regimens
title_short Efficacy of the combination use of aprepitant and palonosetron for improving nausea in various moderately emetogenic chemotherapy regimens
title_sort efficacy of the combination use of aprepitant and palonosetron for improving nausea in various moderately emetogenic chemotherapy regimens
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332848/
https://www.ncbi.nlm.nih.gov/pubmed/30642399
http://dx.doi.org/10.1186/s40360-018-0278-2
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