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The Role of Oxidative Stress in the Pathomechanism of Congenital Malformations
Congenital anomalies are significant causes of mortality and morbidity in infancy and childhood. Embryogenesis requires specific signaling pathways to regulate cell proliferation and differentiation. These signaling pathways are sensitive to endogenous and exogenous agents able to produce several st...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332879/ https://www.ncbi.nlm.nih.gov/pubmed/30693064 http://dx.doi.org/10.1155/2018/7404082 |
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author | Laforgia, Nicola Di Mauro, Antonio Favia Guarnieri, Giovanna Varvara, Dora De Cosmo, Lucrezia Panza, Raffaella Capozza, Manuela Baldassarre, Maria Elisabetta Resta, Nicoletta |
author_facet | Laforgia, Nicola Di Mauro, Antonio Favia Guarnieri, Giovanna Varvara, Dora De Cosmo, Lucrezia Panza, Raffaella Capozza, Manuela Baldassarre, Maria Elisabetta Resta, Nicoletta |
author_sort | Laforgia, Nicola |
collection | PubMed |
description | Congenital anomalies are significant causes of mortality and morbidity in infancy and childhood. Embryogenesis requires specific signaling pathways to regulate cell proliferation and differentiation. These signaling pathways are sensitive to endogenous and exogenous agents able to produce several structural changes of the developing fetus. Oxidative stress, due to an imbalance between the production of reactive oxygen species and antioxidant defenses, disrupts signaling pathways with a causative role in birth defects. This review provides a basis for understanding the role of oxidative stress in the pathomechanism of congenital malformations, discussing the mechanisms related to some congenital malformations. New insights in the knowledge of pathomechanism of oxidative stress-related congenital malformations, according to experimental and human studies, represent the basis of possible clinical applications in screening, prevention, and therapies. |
format | Online Article Text |
id | pubmed-6332879 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-63328792019-01-28 The Role of Oxidative Stress in the Pathomechanism of Congenital Malformations Laforgia, Nicola Di Mauro, Antonio Favia Guarnieri, Giovanna Varvara, Dora De Cosmo, Lucrezia Panza, Raffaella Capozza, Manuela Baldassarre, Maria Elisabetta Resta, Nicoletta Oxid Med Cell Longev Review Article Congenital anomalies are significant causes of mortality and morbidity in infancy and childhood. Embryogenesis requires specific signaling pathways to regulate cell proliferation and differentiation. These signaling pathways are sensitive to endogenous and exogenous agents able to produce several structural changes of the developing fetus. Oxidative stress, due to an imbalance between the production of reactive oxygen species and antioxidant defenses, disrupts signaling pathways with a causative role in birth defects. This review provides a basis for understanding the role of oxidative stress in the pathomechanism of congenital malformations, discussing the mechanisms related to some congenital malformations. New insights in the knowledge of pathomechanism of oxidative stress-related congenital malformations, according to experimental and human studies, represent the basis of possible clinical applications in screening, prevention, and therapies. Hindawi 2018-12-30 /pmc/articles/PMC6332879/ /pubmed/30693064 http://dx.doi.org/10.1155/2018/7404082 Text en Copyright © 2018 Nicola Laforgia et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Laforgia, Nicola Di Mauro, Antonio Favia Guarnieri, Giovanna Varvara, Dora De Cosmo, Lucrezia Panza, Raffaella Capozza, Manuela Baldassarre, Maria Elisabetta Resta, Nicoletta The Role of Oxidative Stress in the Pathomechanism of Congenital Malformations |
title | The Role of Oxidative Stress in the Pathomechanism of Congenital Malformations |
title_full | The Role of Oxidative Stress in the Pathomechanism of Congenital Malformations |
title_fullStr | The Role of Oxidative Stress in the Pathomechanism of Congenital Malformations |
title_full_unstemmed | The Role of Oxidative Stress in the Pathomechanism of Congenital Malformations |
title_short | The Role of Oxidative Stress in the Pathomechanism of Congenital Malformations |
title_sort | role of oxidative stress in the pathomechanism of congenital malformations |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332879/ https://www.ncbi.nlm.nih.gov/pubmed/30693064 http://dx.doi.org/10.1155/2018/7404082 |
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