Cutaneous Side Effects of Targeted Therapy and Immunotherapy for Advanced Melanoma

Melanoma is one of the most fatal cancers, and its incidence is increasing worldwide. Thanks to the better understanding of the molecular mechanisms involved in the pathogenesis of melanoma, recently new targeted agents have been developed. In this article, we review the current state of knowledge o...

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Detalles Bibliográficos
Autores principales: Russo, Irene, Zorzetto, Ludovica, Chiarion Sileni, Vanna, Alaibac, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332919/
https://www.ncbi.nlm.nih.gov/pubmed/30693134
http://dx.doi.org/10.1155/2018/5036213
Descripción
Sumario:Melanoma is one of the most fatal cancers, and its incidence is increasing worldwide. Thanks to the better understanding of the molecular mechanisms involved in the pathogenesis of melanoma, recently new targeted agents have been developed. In this article, we review the current state of knowledge of clinical presentation, mechanisms, and management of the most common cutaneous side effects observed during treatment with targeted and immunological therapies approved for advanced melanoma. We include discussion of BRAF/MEK inhibitors and immune-checkpoint inhibitors, notably CTLA-4 and PD-1 inhibitors.

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