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Optical Coherence Tomography Angiography in Papilledema Compared With Pseudopapilledema
PURPOSE: The purpose of this study is to evaluate differences in optical coherence tomography angiography (OCT-A) findings between patients with papilledema and pseudopapilledema. METHODS: In this prospective, comparative study, 41 eyes of 21 subjects with papilledema, 27 eyes of 15 subjects with ps...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333108/ https://www.ncbi.nlm.nih.gov/pubmed/30640969 http://dx.doi.org/10.1167/iovs.18-25453 |
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author | Fard, Masoud Aghsaei Sahraiyan, Alireza Jalili, Jalil Hejazi, Marjane Suwan, Yanin Ritch, Robert Subramanian, Prem S. |
author_facet | Fard, Masoud Aghsaei Sahraiyan, Alireza Jalili, Jalil Hejazi, Marjane Suwan, Yanin Ritch, Robert Subramanian, Prem S. |
author_sort | Fard, Masoud Aghsaei |
collection | PubMed |
description | PURPOSE: The purpose of this study is to evaluate differences in optical coherence tomography angiography (OCT-A) findings between patients with papilledema and pseudopapilledema. METHODS: In this prospective, comparative study, 41 eyes of 21 subjects with papilledema, 27 eyes of 15 subjects with pseudopapilledema, and 44 eyes of 44 healthy normal subjects were included and were imaged using OCT-A. In addition to peripapillary total vasculature maps obtained with commercial vessel density mapping, major vessel removal using customized image analysis software was also used to measure whole image capillary density and peripapillary capillary density (PCD). Peripapiilary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC) were recorded. RESULTS: Average RNFL thicknesses were greater in papilledema eyes than in pseudopapilledema and control subjects. GCC thickness was not different among three groups. Peripapillary vasculature values were significantly lower in papilledema (58.5 ± 6.1%) and pseudopapilledema (58.9 ± 4.7%) eyes compared with healthy eyes (63.2 ± 3.1%) using commercial machine software, without a difference between papilledema and pseudopapilledema eyes. However, using our customized software, peripapillary “capillary” density of papilledema eyes was 29.8 ± 9.4%, which was not significantly different from healthy subjects (31.8 ± 7.4%; P = 0.94). Pseudopapilledema eyes with peripapillary density of 25.5 ± 8.3% had significantly lower capillary values compared with control eyes (P = 0.01). There was a significantly lower whole image and nasal sector peripapillary capillary density of inner retina in pseudopapilledema eyes than papilledema eyes (P = 0.03 and P = 0.02, respectively). CONCLUSIONS: Whole image and nasal peripapillary sector capillary densities using OCT-A had diagnostic accuracy for differentiating true and pseudo-disc swelling. |
format | Online Article Text |
id | pubmed-6333108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Association for Research in Vision and Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-63331082019-01-16 Optical Coherence Tomography Angiography in Papilledema Compared With Pseudopapilledema Fard, Masoud Aghsaei Sahraiyan, Alireza Jalili, Jalil Hejazi, Marjane Suwan, Yanin Ritch, Robert Subramanian, Prem S. Invest Ophthalmol Vis Sci Eye Movements, Strabismus, Amblyopia and Neuro-Ophthalmology PURPOSE: The purpose of this study is to evaluate differences in optical coherence tomography angiography (OCT-A) findings between patients with papilledema and pseudopapilledema. METHODS: In this prospective, comparative study, 41 eyes of 21 subjects with papilledema, 27 eyes of 15 subjects with pseudopapilledema, and 44 eyes of 44 healthy normal subjects were included and were imaged using OCT-A. In addition to peripapillary total vasculature maps obtained with commercial vessel density mapping, major vessel removal using customized image analysis software was also used to measure whole image capillary density and peripapillary capillary density (PCD). Peripapiilary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC) were recorded. RESULTS: Average RNFL thicknesses were greater in papilledema eyes than in pseudopapilledema and control subjects. GCC thickness was not different among three groups. Peripapillary vasculature values were significantly lower in papilledema (58.5 ± 6.1%) and pseudopapilledema (58.9 ± 4.7%) eyes compared with healthy eyes (63.2 ± 3.1%) using commercial machine software, without a difference between papilledema and pseudopapilledema eyes. However, using our customized software, peripapillary “capillary” density of papilledema eyes was 29.8 ± 9.4%, which was not significantly different from healthy subjects (31.8 ± 7.4%; P = 0.94). Pseudopapilledema eyes with peripapillary density of 25.5 ± 8.3% had significantly lower capillary values compared with control eyes (P = 0.01). There was a significantly lower whole image and nasal sector peripapillary capillary density of inner retina in pseudopapilledema eyes than papilledema eyes (P = 0.03 and P = 0.02, respectively). CONCLUSIONS: Whole image and nasal peripapillary sector capillary densities using OCT-A had diagnostic accuracy for differentiating true and pseudo-disc swelling. The Association for Research in Vision and Ophthalmology 2019-01 /pmc/articles/PMC6333108/ /pubmed/30640969 http://dx.doi.org/10.1167/iovs.18-25453 Text en Copyright 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. |
spellingShingle | Eye Movements, Strabismus, Amblyopia and Neuro-Ophthalmology Fard, Masoud Aghsaei Sahraiyan, Alireza Jalili, Jalil Hejazi, Marjane Suwan, Yanin Ritch, Robert Subramanian, Prem S. Optical Coherence Tomography Angiography in Papilledema Compared With Pseudopapilledema |
title | Optical Coherence Tomography Angiography in Papilledema Compared With Pseudopapilledema |
title_full | Optical Coherence Tomography Angiography in Papilledema Compared With Pseudopapilledema |
title_fullStr | Optical Coherence Tomography Angiography in Papilledema Compared With Pseudopapilledema |
title_full_unstemmed | Optical Coherence Tomography Angiography in Papilledema Compared With Pseudopapilledema |
title_short | Optical Coherence Tomography Angiography in Papilledema Compared With Pseudopapilledema |
title_sort | optical coherence tomography angiography in papilledema compared with pseudopapilledema |
topic | Eye Movements, Strabismus, Amblyopia and Neuro-Ophthalmology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333108/ https://www.ncbi.nlm.nih.gov/pubmed/30640969 http://dx.doi.org/10.1167/iovs.18-25453 |
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