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A dosimetric analysis of a spine SBRT specific treatment planning system

PURPOSE: The Brainlab Elements treatment planning system utilizes distinct modules for treatment planning specific to stereotactic treatment sites including single or multiple brain lesions as well as spine. This work investigates the hypothesis that an optimization tailored specifically to spine ca...

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Autores principales: Saenz, Daniel L., Crownover, Richard, Stathakis, Sotirios, Papanikolaou, Niko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333144/
https://www.ncbi.nlm.nih.gov/pubmed/30461183
http://dx.doi.org/10.1002/acm2.12499
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author Saenz, Daniel L.
Crownover, Richard
Stathakis, Sotirios
Papanikolaou, Niko
author_facet Saenz, Daniel L.
Crownover, Richard
Stathakis, Sotirios
Papanikolaou, Niko
author_sort Saenz, Daniel L.
collection PubMed
description PURPOSE: The Brainlab Elements treatment planning system utilizes distinct modules for treatment planning specific to stereotactic treatment sites including single or multiple brain lesions as well as spine. This work investigates the hypothesis that an optimization tailored specifically to spine can in fact create dosimetrically superior plans to those created in more general use treatment planning systems (TPS). METHODS: Ten spine patients at our institution were replanned in Brainlab Elements, Phillips Pinnacle(3), and Elekta Monaco. The planning target volume (PTV) included the vertebral body (in either the thoracic or lumbar spine), pedicles, and transverse processes. In all plans, the target was prescribed 20 Gy to 95% of the PTV. Objectives for the study included D5%<25 Gy and spinal cord D0.035cc < 14 Gy. Plans were evaluated by the satisfaction of the objectives as well total monitor units (MU), gradient index (GI), conformity index (CI), and dose gradient (distance between 100% and 50% isodose lines) in a selected slice between the vertebral body and spinal cord. RESULTS: All TPS produced clinically acceptable plans. The sharpest dose gradient was achieved with Elements (mean 3.3 ± 0.2 mm). This resulted in lowest spinal cord maximum point doses (6.6 ± 1.0 Gy). Gradient indices were also the smallest for Elements (3.6 ± 0.5). Further improvement in gradient index and spinal cord sparing were not performed due to the subsequent violation of the PTV D5% < 25 Gy constraint or the loss of conformity due to the loss of coverage at the PTV‐spinal canal interface. CONCLUSIONS: Brainlab Elements planning which relies on arc duplication to specifically optimize for spine anatomy did result in dosimetrically superior plans while holding prescription levels constant. While any planning system can improve upon specific dosimetric objectives, the simultaneous satisfaction of all constraints was best achieved with Brainlab Elements.
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spelling pubmed-63331442019-01-23 A dosimetric analysis of a spine SBRT specific treatment planning system Saenz, Daniel L. Crownover, Richard Stathakis, Sotirios Papanikolaou, Niko J Appl Clin Med Phys Radiation Oncology Physics PURPOSE: The Brainlab Elements treatment planning system utilizes distinct modules for treatment planning specific to stereotactic treatment sites including single or multiple brain lesions as well as spine. This work investigates the hypothesis that an optimization tailored specifically to spine can in fact create dosimetrically superior plans to those created in more general use treatment planning systems (TPS). METHODS: Ten spine patients at our institution were replanned in Brainlab Elements, Phillips Pinnacle(3), and Elekta Monaco. The planning target volume (PTV) included the vertebral body (in either the thoracic or lumbar spine), pedicles, and transverse processes. In all plans, the target was prescribed 20 Gy to 95% of the PTV. Objectives for the study included D5%<25 Gy and spinal cord D0.035cc < 14 Gy. Plans were evaluated by the satisfaction of the objectives as well total monitor units (MU), gradient index (GI), conformity index (CI), and dose gradient (distance between 100% and 50% isodose lines) in a selected slice between the vertebral body and spinal cord. RESULTS: All TPS produced clinically acceptable plans. The sharpest dose gradient was achieved with Elements (mean 3.3 ± 0.2 mm). This resulted in lowest spinal cord maximum point doses (6.6 ± 1.0 Gy). Gradient indices were also the smallest for Elements (3.6 ± 0.5). Further improvement in gradient index and spinal cord sparing were not performed due to the subsequent violation of the PTV D5% < 25 Gy constraint or the loss of conformity due to the loss of coverage at the PTV‐spinal canal interface. CONCLUSIONS: Brainlab Elements planning which relies on arc duplication to specifically optimize for spine anatomy did result in dosimetrically superior plans while holding prescription levels constant. While any planning system can improve upon specific dosimetric objectives, the simultaneous satisfaction of all constraints was best achieved with Brainlab Elements. John Wiley and Sons Inc. 2018-11-20 /pmc/articles/PMC6333144/ /pubmed/30461183 http://dx.doi.org/10.1002/acm2.12499 Text en © 2018 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Saenz, Daniel L.
Crownover, Richard
Stathakis, Sotirios
Papanikolaou, Niko
A dosimetric analysis of a spine SBRT specific treatment planning system
title A dosimetric analysis of a spine SBRT specific treatment planning system
title_full A dosimetric analysis of a spine SBRT specific treatment planning system
title_fullStr A dosimetric analysis of a spine SBRT specific treatment planning system
title_full_unstemmed A dosimetric analysis of a spine SBRT specific treatment planning system
title_short A dosimetric analysis of a spine SBRT specific treatment planning system
title_sort dosimetric analysis of a spine sbrt specific treatment planning system
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333144/
https://www.ncbi.nlm.nih.gov/pubmed/30461183
http://dx.doi.org/10.1002/acm2.12499
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