A fruitful tree: developing the dendritic nucleation model of actin-based cell motility

A fundamental question in cell biology concerns how cells move, and this has been the subject of intense research for decades. In the 1990s, a major leap forward was made in our understanding of cell motility, with the proposal of the dendritic nucleation model. This essay describes the events leadi...

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Detalles Bibliográficos
Autor principal: Higgs, Henry N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2018
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333179/
http://dx.doi.org/10.1091/mbc.E18-07-0426
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author Higgs, Henry N.
author_facet Higgs, Henry N.
author_sort Higgs, Henry N.
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description A fundamental question in cell biology concerns how cells move, and this has been the subject of intense research for decades. In the 1990s, a major leap forward was made in our understanding of cell motility, with the proposal of the dendritic nucleation model. This essay describes the events leading to the development of the model, including findings from many laboratories and scientific disciplines. The story is an excellent example of the scientific process in action, with the combination of multiple perspectives leading to robust conclusions.
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spelling pubmed-63331792019-02-16 A fruitful tree: developing the dendritic nucleation model of actin-based cell motility Higgs, Henry N. Mol Biol Cell Perspective A fundamental question in cell biology concerns how cells move, and this has been the subject of intense research for decades. In the 1990s, a major leap forward was made in our understanding of cell motility, with the proposal of the dendritic nucleation model. This essay describes the events leading to the development of the model, including findings from many laboratories and scientific disciplines. The story is an excellent example of the scientific process in action, with the combination of multiple perspectives leading to robust conclusions. The American Society for Cell Biology 2018-12-01 /pmc/articles/PMC6333179/ http://dx.doi.org/10.1091/mbc.E18-07-0426 Text en © 2018 Higgs. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology. http://creativecommons.org/licenses/by-nc-sa/3.0 This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License.
spellingShingle Perspective
Higgs, Henry N.
A fruitful tree: developing the dendritic nucleation model of actin-based cell motility
title A fruitful tree: developing the dendritic nucleation model of actin-based cell motility
title_full A fruitful tree: developing the dendritic nucleation model of actin-based cell motility
title_fullStr A fruitful tree: developing the dendritic nucleation model of actin-based cell motility
title_full_unstemmed A fruitful tree: developing the dendritic nucleation model of actin-based cell motility
title_short A fruitful tree: developing the dendritic nucleation model of actin-based cell motility
title_sort fruitful tree: developing the dendritic nucleation model of actin-based cell motility
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333179/
http://dx.doi.org/10.1091/mbc.E18-07-0426
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