Cargando…
No causal effects of serum urate levels on the risk of chronic kidney disease: A Mendelian randomization study
BACKGROUND: Studies have shown strong positive associations between serum urate (SU) levels and chronic kidney disease (CKD) risk; however, whether the relation is causal remains uncertain. We evaluate whether genetic data are consistent with a causal impact of SU level on the risk of CKD and estima...
Autores principales: | Jordan, Daniel M., Choi, Hyon K., Verbanck, Marie, Topless, Ruth, Won, Hong-Hee, Nadkarni, Girish, Merriman, Tony R., Do, Ron |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333326/ https://www.ncbi.nlm.nih.gov/pubmed/30645594 http://dx.doi.org/10.1371/journal.pmed.1002725 |
Ejemplares similares
-
Evaluation of the diet wide contribution to serum urate levels: meta-analysis of population based cohorts
por: Major, Tanya J, et al.
Publicado: (2018) -
Interactions between serum urate-associated genetic variants and sex on gout risk: analysis of the UK Biobank
por: Narang, Ravi K., et al.
Publicado: (2019) -
Association of SLC2A9 genotype with phenotypic variability of serum urate in pre-menopausal women
por: Topless, Ruth K., et al.
Publicado: (2015) -
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
por: Verbanck, Marie, et al.
Publicado: (2018) -
Mendelian randomization study shows no causal effects of serum urate levels on the risk of MS
por: Harroud, Adil, et al.
Publicado: (2020)