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Plasma growth differentiation factor-15 is an independent marker for aggressive disease in endometrial cancer
OBJECTIVE: Better biomarkers are needed in order to identify patients with endometrial carcinoma at risk of recurrence and who may profit from a more aggressive treatment regimen. Our objective was to explore the applicability of plasma growth differentiation factor 15 (GDF-15) as a marker for recur...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333370/ https://www.ncbi.nlm.nih.gov/pubmed/30645608 http://dx.doi.org/10.1371/journal.pone.0210585 |
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author | Engerud, Hilde Hope, Kirsten Berg, Hege Fredriksen Fasmer, Kristine Eldevik Tangen, Ingvild Løberg Haldorsen, Ingfrid Salvesen Trovik, Jone Krakstad, Camilla |
author_facet | Engerud, Hilde Hope, Kirsten Berg, Hege Fredriksen Fasmer, Kristine Eldevik Tangen, Ingvild Løberg Haldorsen, Ingfrid Salvesen Trovik, Jone Krakstad, Camilla |
author_sort | Engerud, Hilde |
collection | PubMed |
description | OBJECTIVE: Better biomarkers are needed in order to identify patients with endometrial carcinoma at risk of recurrence and who may profit from a more aggressive treatment regimen. Our objective was to explore the applicability of plasma growth differentiation factor 15 (GDF-15) as a marker for recurrent disease, as well as a marker for poor prognosis and lymph node metastases. METHODS: EDTA-blood samples were obtained from 235 patients with endometrial cancer before primary surgery. For 36 of these patients, matching blood samples were collected at time of recurrence. Blood samples were also collected from 78 patients with endometrial hyperplasia. Plasma GDF-15 was measured by an enzyme-linked immunosorbent assay (ELISA). Preoperative pelvic MRI scans for 141 patients were investigated in parallel for imaging variables. RESULTS: Preoperative plasma level of GDF-15 was significantly higher for patients who experienced recurrence (1780 ng/L; 95% CI; 518–9475 ng/L) than for patients who did not develop recurrent disease (1236 ng/L; 95% CI; 307–7030 ng/L) (p<0.001). Plasma levels of GDF-15 at recurrence (2818 ng/L, 95% CI 2088–3548 ng/L) were significantly higher than plasma levels of GDF-15 measured at time of primary diagnosis (1857 ng/L, 95% CI; 1317–2398 ng/L) (p = 0.001). High plasma level GDF-15 independently predicts recurrent disease (OR = 3.14; 95% CI 2.10–4.76) and lymph node metastases (OR = 2.64; 95% CI 1.52–4.61). Patients with high plasma level of GDF-15 had significantly larger tumor volume (p = 0.008). CONCLUSION: Elevated plasma level of GDF-15 is associated with aggressive disease and lymph node metastasis in endometrial carcinoma. GDF-15 may be helpful in indicating recurrent disease. |
format | Online Article Text |
id | pubmed-6333370 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-63333702019-01-31 Plasma growth differentiation factor-15 is an independent marker for aggressive disease in endometrial cancer Engerud, Hilde Hope, Kirsten Berg, Hege Fredriksen Fasmer, Kristine Eldevik Tangen, Ingvild Løberg Haldorsen, Ingfrid Salvesen Trovik, Jone Krakstad, Camilla PLoS One Research Article OBJECTIVE: Better biomarkers are needed in order to identify patients with endometrial carcinoma at risk of recurrence and who may profit from a more aggressive treatment regimen. Our objective was to explore the applicability of plasma growth differentiation factor 15 (GDF-15) as a marker for recurrent disease, as well as a marker for poor prognosis and lymph node metastases. METHODS: EDTA-blood samples were obtained from 235 patients with endometrial cancer before primary surgery. For 36 of these patients, matching blood samples were collected at time of recurrence. Blood samples were also collected from 78 patients with endometrial hyperplasia. Plasma GDF-15 was measured by an enzyme-linked immunosorbent assay (ELISA). Preoperative pelvic MRI scans for 141 patients were investigated in parallel for imaging variables. RESULTS: Preoperative plasma level of GDF-15 was significantly higher for patients who experienced recurrence (1780 ng/L; 95% CI; 518–9475 ng/L) than for patients who did not develop recurrent disease (1236 ng/L; 95% CI; 307–7030 ng/L) (p<0.001). Plasma levels of GDF-15 at recurrence (2818 ng/L, 95% CI 2088–3548 ng/L) were significantly higher than plasma levels of GDF-15 measured at time of primary diagnosis (1857 ng/L, 95% CI; 1317–2398 ng/L) (p = 0.001). High plasma level GDF-15 independently predicts recurrent disease (OR = 3.14; 95% CI 2.10–4.76) and lymph node metastases (OR = 2.64; 95% CI 1.52–4.61). Patients with high plasma level of GDF-15 had significantly larger tumor volume (p = 0.008). CONCLUSION: Elevated plasma level of GDF-15 is associated with aggressive disease and lymph node metastasis in endometrial carcinoma. GDF-15 may be helpful in indicating recurrent disease. Public Library of Science 2019-01-15 /pmc/articles/PMC6333370/ /pubmed/30645608 http://dx.doi.org/10.1371/journal.pone.0210585 Text en © 2019 Engerud et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Engerud, Hilde Hope, Kirsten Berg, Hege Fredriksen Fasmer, Kristine Eldevik Tangen, Ingvild Løberg Haldorsen, Ingfrid Salvesen Trovik, Jone Krakstad, Camilla Plasma growth differentiation factor-15 is an independent marker for aggressive disease in endometrial cancer |
title | Plasma growth differentiation factor-15 is an independent marker for aggressive disease in endometrial cancer |
title_full | Plasma growth differentiation factor-15 is an independent marker for aggressive disease in endometrial cancer |
title_fullStr | Plasma growth differentiation factor-15 is an independent marker for aggressive disease in endometrial cancer |
title_full_unstemmed | Plasma growth differentiation factor-15 is an independent marker for aggressive disease in endometrial cancer |
title_short | Plasma growth differentiation factor-15 is an independent marker for aggressive disease in endometrial cancer |
title_sort | plasma growth differentiation factor-15 is an independent marker for aggressive disease in endometrial cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333370/ https://www.ncbi.nlm.nih.gov/pubmed/30645608 http://dx.doi.org/10.1371/journal.pone.0210585 |
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