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Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections

BACKGROUND: Periprosthetic joint infections (PJIs) have a high incidence of recurrence after total joint replacement and are difficult to treat by debridement or antibiotic treatment. Curcumin is a natural product with anti-inflammatory and anti-bacterial properties. The low bioactivity of curcumin...

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Autores principales: Peng, Kuo-Ti, Chiang, Yao-Chang, Huang, Tsung-Yu, Chen, Pei-Chun, Chang, Pey-Jium, Lee, Chiang-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333393/
https://www.ncbi.nlm.nih.gov/pubmed/30666108
http://dx.doi.org/10.2147/IJN.S191504
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author Peng, Kuo-Ti
Chiang, Yao-Chang
Huang, Tsung-Yu
Chen, Pei-Chun
Chang, Pey-Jium
Lee, Chiang-Wen
author_facet Peng, Kuo-Ti
Chiang, Yao-Chang
Huang, Tsung-Yu
Chen, Pei-Chun
Chang, Pey-Jium
Lee, Chiang-Wen
author_sort Peng, Kuo-Ti
collection PubMed
description BACKGROUND: Periprosthetic joint infections (PJIs) have a high incidence of recurrence after total joint replacement and are difficult to treat by debridement or antibiotic treatment. Curcumin is a natural product with anti-inflammatory and anti-bacterial properties. The low bioactivity of curcumin in water restricts its clinical application. Curcumin nanoparticles (CURN) were developed to overcome this limitation. METHODS: In this study, the therapeutic effects of CURN and their anti-inflammatory functions were investigated in a Staphylococcus aureus biofilm-induced PJIs model. RESULTS: CURN first attenuated the biofilm-induced expansion of myeloid-derived suppressor cells (MDSCs) and then regulated M1- and M2-phenotypic MDSC expression. Down-regulation of cytokines and reactive oxygen species was considered as the mechanism of CURN in reversing the suppression of T cell proliferation. The recovery of bone permeative destruction demonstrated that CURN enhanced therapeutic potency of vancomycin in vivo. CONCLUSION: This is the first study to demonstrate that CURN may be useful for treating PJIs.
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spelling pubmed-63333932019-01-21 Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections Peng, Kuo-Ti Chiang, Yao-Chang Huang, Tsung-Yu Chen, Pei-Chun Chang, Pey-Jium Lee, Chiang-Wen Int J Nanomedicine Original Research BACKGROUND: Periprosthetic joint infections (PJIs) have a high incidence of recurrence after total joint replacement and are difficult to treat by debridement or antibiotic treatment. Curcumin is a natural product with anti-inflammatory and anti-bacterial properties. The low bioactivity of curcumin in water restricts its clinical application. Curcumin nanoparticles (CURN) were developed to overcome this limitation. METHODS: In this study, the therapeutic effects of CURN and their anti-inflammatory functions were investigated in a Staphylococcus aureus biofilm-induced PJIs model. RESULTS: CURN first attenuated the biofilm-induced expansion of myeloid-derived suppressor cells (MDSCs) and then regulated M1- and M2-phenotypic MDSC expression. Down-regulation of cytokines and reactive oxygen species was considered as the mechanism of CURN in reversing the suppression of T cell proliferation. The recovery of bone permeative destruction demonstrated that CURN enhanced therapeutic potency of vancomycin in vivo. CONCLUSION: This is the first study to demonstrate that CURN may be useful for treating PJIs. Dove Medical Press 2019-01-11 /pmc/articles/PMC6333393/ /pubmed/30666108 http://dx.doi.org/10.2147/IJN.S191504 Text en © 2019 Peng et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Peng, Kuo-Ti
Chiang, Yao-Chang
Huang, Tsung-Yu
Chen, Pei-Chun
Chang, Pey-Jium
Lee, Chiang-Wen
Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections
title Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections
title_full Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections
title_fullStr Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections
title_full_unstemmed Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections
title_short Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections
title_sort curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333393/
https://www.ncbi.nlm.nih.gov/pubmed/30666108
http://dx.doi.org/10.2147/IJN.S191504
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