Cargando…
Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections
BACKGROUND: Periprosthetic joint infections (PJIs) have a high incidence of recurrence after total joint replacement and are difficult to treat by debridement or antibiotic treatment. Curcumin is a natural product with anti-inflammatory and anti-bacterial properties. The low bioactivity of curcumin...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333393/ https://www.ncbi.nlm.nih.gov/pubmed/30666108 http://dx.doi.org/10.2147/IJN.S191504 |
_version_ | 1783387556246716416 |
---|---|
author | Peng, Kuo-Ti Chiang, Yao-Chang Huang, Tsung-Yu Chen, Pei-Chun Chang, Pey-Jium Lee, Chiang-Wen |
author_facet | Peng, Kuo-Ti Chiang, Yao-Chang Huang, Tsung-Yu Chen, Pei-Chun Chang, Pey-Jium Lee, Chiang-Wen |
author_sort | Peng, Kuo-Ti |
collection | PubMed |
description | BACKGROUND: Periprosthetic joint infections (PJIs) have a high incidence of recurrence after total joint replacement and are difficult to treat by debridement or antibiotic treatment. Curcumin is a natural product with anti-inflammatory and anti-bacterial properties. The low bioactivity of curcumin in water restricts its clinical application. Curcumin nanoparticles (CURN) were developed to overcome this limitation. METHODS: In this study, the therapeutic effects of CURN and their anti-inflammatory functions were investigated in a Staphylococcus aureus biofilm-induced PJIs model. RESULTS: CURN first attenuated the biofilm-induced expansion of myeloid-derived suppressor cells (MDSCs) and then regulated M1- and M2-phenotypic MDSC expression. Down-regulation of cytokines and reactive oxygen species was considered as the mechanism of CURN in reversing the suppression of T cell proliferation. The recovery of bone permeative destruction demonstrated that CURN enhanced therapeutic potency of vancomycin in vivo. CONCLUSION: This is the first study to demonstrate that CURN may be useful for treating PJIs. |
format | Online Article Text |
id | pubmed-6333393 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-63333932019-01-21 Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections Peng, Kuo-Ti Chiang, Yao-Chang Huang, Tsung-Yu Chen, Pei-Chun Chang, Pey-Jium Lee, Chiang-Wen Int J Nanomedicine Original Research BACKGROUND: Periprosthetic joint infections (PJIs) have a high incidence of recurrence after total joint replacement and are difficult to treat by debridement or antibiotic treatment. Curcumin is a natural product with anti-inflammatory and anti-bacterial properties. The low bioactivity of curcumin in water restricts its clinical application. Curcumin nanoparticles (CURN) were developed to overcome this limitation. METHODS: In this study, the therapeutic effects of CURN and their anti-inflammatory functions were investigated in a Staphylococcus aureus biofilm-induced PJIs model. RESULTS: CURN first attenuated the biofilm-induced expansion of myeloid-derived suppressor cells (MDSCs) and then regulated M1- and M2-phenotypic MDSC expression. Down-regulation of cytokines and reactive oxygen species was considered as the mechanism of CURN in reversing the suppression of T cell proliferation. The recovery of bone permeative destruction demonstrated that CURN enhanced therapeutic potency of vancomycin in vivo. CONCLUSION: This is the first study to demonstrate that CURN may be useful for treating PJIs. Dove Medical Press 2019-01-11 /pmc/articles/PMC6333393/ /pubmed/30666108 http://dx.doi.org/10.2147/IJN.S191504 Text en © 2019 Peng et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Peng, Kuo-Ti Chiang, Yao-Chang Huang, Tsung-Yu Chen, Pei-Chun Chang, Pey-Jium Lee, Chiang-Wen Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections |
title | Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections |
title_full | Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections |
title_fullStr | Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections |
title_full_unstemmed | Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections |
title_short | Curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections |
title_sort | curcumin nanoparticles are a promising anti-bacterial and anti-inflammatory agent for treating periprosthetic joint infections |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333393/ https://www.ncbi.nlm.nih.gov/pubmed/30666108 http://dx.doi.org/10.2147/IJN.S191504 |
work_keys_str_mv | AT pengkuoti curcuminnanoparticlesareapromisingantibacterialandantiinflammatoryagentfortreatingperiprostheticjointinfections AT chiangyaochang curcuminnanoparticlesareapromisingantibacterialandantiinflammatoryagentfortreatingperiprostheticjointinfections AT huangtsungyu curcuminnanoparticlesareapromisingantibacterialandantiinflammatoryagentfortreatingperiprostheticjointinfections AT chenpeichun curcuminnanoparticlesareapromisingantibacterialandantiinflammatoryagentfortreatingperiprostheticjointinfections AT changpeyjium curcuminnanoparticlesareapromisingantibacterialandantiinflammatoryagentfortreatingperiprostheticjointinfections AT leechiangwen curcuminnanoparticlesareapromisingantibacterialandantiinflammatoryagentfortreatingperiprostheticjointinfections |