CRISPR-Cas9 interrogation of a putative fetal globin repressor in human erythroid cells

Sickle Cell Disease and ß-thalassemia, which are caused by defective or deficient adult ß-globin (HBB) respectively, are the most common serious genetic blood diseases in the world. Persistent expression of the fetal ß-like globin, also known as 𝛾-globin, can ameliorate both disorders by serving in...

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Detalles Bibliográficos
Autores principales: Chung, Jennifer E., Magis, Wendy, Vu, Jonathan, Heo, Seok-Jin, Wartiovaara, Kirmo, Walters, Mark C., Kurita, Ryo, Nakamura, Yukio, Boffelli, Dario, Martin, David I. K., Corn, Jacob E., DeWitt, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333401/
https://www.ncbi.nlm.nih.gov/pubmed/30645582
http://dx.doi.org/10.1371/journal.pone.0208237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333401/
https://www.ncbi.nlm.nih.gov/pubmed/30645582
http://dx.doi.org/10.1371/journal.pone.0208237

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