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Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity

The Transient Receptor Potential Vanilloid 1 (TRPV) channel is activated by an array of stimuli, including heat and vanilloid compounds. The TRPV1 homologues TRPV2 and TRPV3 are also activated by heat, but sensitivity to vanilloids and many other agonists is not conserved among TRPV subfamily member...

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Detalles Bibliográficos
Autores principales:	Zhang, Feng, Swartz, Kenton Jon, Jara-Oseguera, Andres
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333442/ https://www.ncbi.nlm.nih.gov/pubmed/30644819 http://dx.doi.org/10.7554/eLife.42756

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