Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

We use a genome-wide association of 1 million parental lifespans of genotyped subjects and data on mortality risk factors to validate previously unreplicated findings near CDKN2B-AS1, ATXN2/BRAP, FURIN/FES, ZW10, PSORS1C3, and 13q21.31, and identify and replicate novel findings near ABO, ZC3HC1, and...

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Detalles Bibliográficos
Autores principales: Timmers, Paul RHJ, Mounier, Ninon, Lall, Kristi, Fischer, Krista, Ning, Zheng, Feng, Xiao, Bretherick, Andrew D, Clark, David W, Shen, Xia, Esko, Tõnu, Kutalik, Zoltán, Wilson, James F, Joshi, Peter K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333444/
https://www.ncbi.nlm.nih.gov/pubmed/30642433
http://dx.doi.org/10.7554/eLife.39856

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