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Multifactorial processes underlie parallel opsin loss in neotropical bats

The loss of previously adaptive traits is typically linked to relaxation in selection, yet the molecular steps leading to such repeated losses are rarely known. Molecular studies of loss have tended to focus on gene sequences alone, but overlooking other aspects of protein expression might underesti...

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Autores principales: Sadier, Alexa, Davies, Kalina TJ, Yohe, Laurel R, Yun, Kun, Donat, Paul, Hedrick, Brandon P, Dumont, Elizabeth R, Dávalos, Liliana M, Rossiter, Stephen J, Sears, Karen E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333445/
https://www.ncbi.nlm.nih.gov/pubmed/30560780
http://dx.doi.org/10.7554/eLife.37412
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author Sadier, Alexa
Davies, Kalina TJ
Yohe, Laurel R
Yun, Kun
Donat, Paul
Hedrick, Brandon P
Dumont, Elizabeth R
Dávalos, Liliana M
Rossiter, Stephen J
Sears, Karen E
author_facet Sadier, Alexa
Davies, Kalina TJ
Yohe, Laurel R
Yun, Kun
Donat, Paul
Hedrick, Brandon P
Dumont, Elizabeth R
Dávalos, Liliana M
Rossiter, Stephen J
Sears, Karen E
author_sort Sadier, Alexa
collection PubMed
description The loss of previously adaptive traits is typically linked to relaxation in selection, yet the molecular steps leading to such repeated losses are rarely known. Molecular studies of loss have tended to focus on gene sequences alone, but overlooking other aspects of protein expression might underestimate phenotypic diversity. Insights based almost solely on opsin gene evolution, for instance, have made mammalian color vision a textbook example of phenotypic loss. We address this gap by investigating retention and loss of opsin genes, transcripts, and proteins across ecologically diverse noctilionoid bats. We find multiple, independent losses of short-wave-sensitive opsins. Mismatches between putatively functional DNA sequences, mRNA transcripts, and proteins implicate transcriptional and post-transcriptional processes in the ongoing loss of S-opsins in some noctilionoid bats. Our results provide a snapshot of evolution in progress during phenotypic trait loss, and suggest vertebrate visual phenotypes cannot always be predicted from genotypes alone.
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spelling pubmed-63334452019-01-16 Multifactorial processes underlie parallel opsin loss in neotropical bats Sadier, Alexa Davies, Kalina TJ Yohe, Laurel R Yun, Kun Donat, Paul Hedrick, Brandon P Dumont, Elizabeth R Dávalos, Liliana M Rossiter, Stephen J Sears, Karen E eLife Evolutionary Biology The loss of previously adaptive traits is typically linked to relaxation in selection, yet the molecular steps leading to such repeated losses are rarely known. Molecular studies of loss have tended to focus on gene sequences alone, but overlooking other aspects of protein expression might underestimate phenotypic diversity. Insights based almost solely on opsin gene evolution, for instance, have made mammalian color vision a textbook example of phenotypic loss. We address this gap by investigating retention and loss of opsin genes, transcripts, and proteins across ecologically diverse noctilionoid bats. We find multiple, independent losses of short-wave-sensitive opsins. Mismatches between putatively functional DNA sequences, mRNA transcripts, and proteins implicate transcriptional and post-transcriptional processes in the ongoing loss of S-opsins in some noctilionoid bats. Our results provide a snapshot of evolution in progress during phenotypic trait loss, and suggest vertebrate visual phenotypes cannot always be predicted from genotypes alone. eLife Sciences Publications, Ltd 2018-12-18 /pmc/articles/PMC6333445/ /pubmed/30560780 http://dx.doi.org/10.7554/eLife.37412 Text en © 2018, Sadier et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Evolutionary Biology
Sadier, Alexa
Davies, Kalina TJ
Yohe, Laurel R
Yun, Kun
Donat, Paul
Hedrick, Brandon P
Dumont, Elizabeth R
Dávalos, Liliana M
Rossiter, Stephen J
Sears, Karen E
Multifactorial processes underlie parallel opsin loss in neotropical bats
title Multifactorial processes underlie parallel opsin loss in neotropical bats
title_full Multifactorial processes underlie parallel opsin loss in neotropical bats
title_fullStr Multifactorial processes underlie parallel opsin loss in neotropical bats
title_full_unstemmed Multifactorial processes underlie parallel opsin loss in neotropical bats
title_short Multifactorial processes underlie parallel opsin loss in neotropical bats
title_sort multifactorial processes underlie parallel opsin loss in neotropical bats
topic Evolutionary Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333445/
https://www.ncbi.nlm.nih.gov/pubmed/30560780
http://dx.doi.org/10.7554/eLife.37412
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