CRISPR/Cas9-mediated knockout of Rag-2 causes systemic lymphopenia with hypoplastic lymphoid organs in FVB mice

Recombination activating gene-2 (RAG-2) plays a crucial role in the development of lymphocytes by mediating recombination of T cell receptors and immunoglobulins, and loss of RAG-2 causes severe combined immunodeficiency (SCID) in humans. RAG-2 knockout mice created using homologous recombination in...

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Detalles Bibliográficos
Autores principales: Kim, Joo-Il, Park, Jin-Sung, Kim, Hanna, Ryu, Soo-Kyung, Kwak, Jina, Kwon, Euna, Yun, Jun-Won, Nam, Ki-Taek, Lee, Han-Woong, Kang, Byeong-Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for Laboratory Animal Science 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333597/
https://www.ncbi.nlm.nih.gov/pubmed/30671102
http://dx.doi.org/10.5625/lar.2018.34.4.166

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