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Generation of knockout mouse models of cyclin-dependent kinase inhibitors by engineered nuclease-mediated genome editing

Cell cycle dysfunction can cause severe diseases, including neurodegenerative disease and cancer. Mutations in cyclin-dependent kinase inhibitors controlling the G1 phase of the cell cycle are prevalent in various cancers. Mice lacking the tumor suppressors p16(Ink4a) (Cdkn2a, cyclin-dependent kinas...

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Detalles Bibliográficos
Autores principales:	Park, Bo Min, Roh, Jae-il, Lee, Jaehoon, Lee, Han-Woong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Association for Laboratory Animal Science 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333600/ https://www.ncbi.nlm.nih.gov/pubmed/30671114 http://dx.doi.org/10.5625/lar.2018.34.4.264

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