Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging

Optical coherence tomography angiography relies on motion for contrast and requires at least two data acquisitions per pointwise scanning location. We present a method termed spectral contrast optical coherence tomography angiography using visible light that relies on the spectral signatures of bloo...

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Detalles Bibliográficos
Autores principales: Winkelmann, James A., Eid, Aya, Spicer, Graham, Almassalha, Luay M., Nguyen, The-Quyen, Backman, Vadim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333625/
https://www.ncbi.nlm.nih.gov/pubmed/30651982
http://dx.doi.org/10.1038/s41377-018-0117-7
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author Winkelmann, James A.
Eid, Aya
Spicer, Graham
Almassalha, Luay M.
Nguyen, The-Quyen
Backman, Vadim
author_facet Winkelmann, James A.
Eid, Aya
Spicer, Graham
Almassalha, Luay M.
Nguyen, The-Quyen
Backman, Vadim
author_sort Winkelmann, James A.
collection PubMed
description Optical coherence tomography angiography relies on motion for contrast and requires at least two data acquisitions per pointwise scanning location. We present a method termed spectral contrast optical coherence tomography angiography using visible light that relies on the spectral signatures of blood for angiography from a single scan using endogenous contrast. We demonstrate the molecular sensitivity of this method, which enables lymphatic vessel, blood, and tissue discrimination.
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spelling pubmed-63336252019-01-16 Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging Winkelmann, James A. Eid, Aya Spicer, Graham Almassalha, Luay M. Nguyen, The-Quyen Backman, Vadim Light Sci Appl Letter Optical coherence tomography angiography relies on motion for contrast and requires at least two data acquisitions per pointwise scanning location. We present a method termed spectral contrast optical coherence tomography angiography using visible light that relies on the spectral signatures of blood for angiography from a single scan using endogenous contrast. We demonstrate the molecular sensitivity of this method, which enables lymphatic vessel, blood, and tissue discrimination. Nature Publishing Group UK 2019-01-16 /pmc/articles/PMC6333625/ /pubmed/30651982 http://dx.doi.org/10.1038/s41377-018-0117-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Letter
Winkelmann, James A.
Eid, Aya
Spicer, Graham
Almassalha, Luay M.
Nguyen, The-Quyen
Backman, Vadim
Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging
title Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging
title_full Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging
title_fullStr Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging
title_full_unstemmed Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging
title_short Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging
title_sort spectral contrast optical coherence tomography angiography enables single-scan vessel imaging
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333625/
https://www.ncbi.nlm.nih.gov/pubmed/30651982
http://dx.doi.org/10.1038/s41377-018-0117-7
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