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Hallmarks of Aging: An Autophagic Perspective
Autophagy is a major protein turnover pathway by which cellular components are delivered into the lysosomes for degradation and recycling. This intracellular process is able to maintain cellular homeostasis under stress conditions, and its dysregulation could lead to the development of physiological...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333684/ https://www.ncbi.nlm.nih.gov/pubmed/30687233 http://dx.doi.org/10.3389/fendo.2018.00790 |
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author | Barbosa, María Carolina Grosso, Rubén Adrián Fader, Claudio Marcelo |
author_facet | Barbosa, María Carolina Grosso, Rubén Adrián Fader, Claudio Marcelo |
author_sort | Barbosa, María Carolina |
collection | PubMed |
description | Autophagy is a major protein turnover pathway by which cellular components are delivered into the lysosomes for degradation and recycling. This intracellular process is able to maintain cellular homeostasis under stress conditions, and its dysregulation could lead to the development of physiological alterations. The autophagic activity has been found to decrease with age, likely contributing to the accumulation of damaged macromolecules and organelles during aging. Interestingly, failure of the autophagic process has been reported to worsen aging-associated diseases, such as neurodegeneration or cancer, among others. Likewise, it has been proposed in different organisms that maintenance of a proper autophagic activity contributes to extending longevity. In this review, we discuss recent papers showing the impact of autophagy on cell activity and age-associated diseases, highlighting the relevance of this process to the hallmarks of aging. Thus, understanding how autophagy plays an important role in aging opens new avenues for the discovery of biochemical and pharmacological targets and the development of novel anti-aging therapeutic approaches. |
format | Online Article Text |
id | pubmed-6333684 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63336842019-01-25 Hallmarks of Aging: An Autophagic Perspective Barbosa, María Carolina Grosso, Rubén Adrián Fader, Claudio Marcelo Front Endocrinol (Lausanne) Endocrinology Autophagy is a major protein turnover pathway by which cellular components are delivered into the lysosomes for degradation and recycling. This intracellular process is able to maintain cellular homeostasis under stress conditions, and its dysregulation could lead to the development of physiological alterations. The autophagic activity has been found to decrease with age, likely contributing to the accumulation of damaged macromolecules and organelles during aging. Interestingly, failure of the autophagic process has been reported to worsen aging-associated diseases, such as neurodegeneration or cancer, among others. Likewise, it has been proposed in different organisms that maintenance of a proper autophagic activity contributes to extending longevity. In this review, we discuss recent papers showing the impact of autophagy on cell activity and age-associated diseases, highlighting the relevance of this process to the hallmarks of aging. Thus, understanding how autophagy plays an important role in aging opens new avenues for the discovery of biochemical and pharmacological targets and the development of novel anti-aging therapeutic approaches. Frontiers Media S.A. 2019-01-09 /pmc/articles/PMC6333684/ /pubmed/30687233 http://dx.doi.org/10.3389/fendo.2018.00790 Text en Copyright © 2019 Barbosa, Grosso and Fader. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Barbosa, María Carolina Grosso, Rubén Adrián Fader, Claudio Marcelo Hallmarks of Aging: An Autophagic Perspective |
title | Hallmarks of Aging: An Autophagic Perspective |
title_full | Hallmarks of Aging: An Autophagic Perspective |
title_fullStr | Hallmarks of Aging: An Autophagic Perspective |
title_full_unstemmed | Hallmarks of Aging: An Autophagic Perspective |
title_short | Hallmarks of Aging: An Autophagic Perspective |
title_sort | hallmarks of aging: an autophagic perspective |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333684/ https://www.ncbi.nlm.nih.gov/pubmed/30687233 http://dx.doi.org/10.3389/fendo.2018.00790 |
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