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Hallmarks of Aging: An Autophagic Perspective

Autophagy is a major protein turnover pathway by which cellular components are delivered into the lysosomes for degradation and recycling. This intracellular process is able to maintain cellular homeostasis under stress conditions, and its dysregulation could lead to the development of physiological...

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Detalles Bibliográficos
Autores principales: Barbosa, María Carolina, Grosso, Rubén Adrián, Fader, Claudio Marcelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333684/
https://www.ncbi.nlm.nih.gov/pubmed/30687233
http://dx.doi.org/10.3389/fendo.2018.00790
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author Barbosa, María Carolina
Grosso, Rubén Adrián
Fader, Claudio Marcelo
author_facet Barbosa, María Carolina
Grosso, Rubén Adrián
Fader, Claudio Marcelo
author_sort Barbosa, María Carolina
collection PubMed
description Autophagy is a major protein turnover pathway by which cellular components are delivered into the lysosomes for degradation and recycling. This intracellular process is able to maintain cellular homeostasis under stress conditions, and its dysregulation could lead to the development of physiological alterations. The autophagic activity has been found to decrease with age, likely contributing to the accumulation of damaged macromolecules and organelles during aging. Interestingly, failure of the autophagic process has been reported to worsen aging-associated diseases, such as neurodegeneration or cancer, among others. Likewise, it has been proposed in different organisms that maintenance of a proper autophagic activity contributes to extending longevity. In this review, we discuss recent papers showing the impact of autophagy on cell activity and age-associated diseases, highlighting the relevance of this process to the hallmarks of aging. Thus, understanding how autophagy plays an important role in aging opens new avenues for the discovery of biochemical and pharmacological targets and the development of novel anti-aging therapeutic approaches.
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spelling pubmed-63336842019-01-25 Hallmarks of Aging: An Autophagic Perspective Barbosa, María Carolina Grosso, Rubén Adrián Fader, Claudio Marcelo Front Endocrinol (Lausanne) Endocrinology Autophagy is a major protein turnover pathway by which cellular components are delivered into the lysosomes for degradation and recycling. This intracellular process is able to maintain cellular homeostasis under stress conditions, and its dysregulation could lead to the development of physiological alterations. The autophagic activity has been found to decrease with age, likely contributing to the accumulation of damaged macromolecules and organelles during aging. Interestingly, failure of the autophagic process has been reported to worsen aging-associated diseases, such as neurodegeneration or cancer, among others. Likewise, it has been proposed in different organisms that maintenance of a proper autophagic activity contributes to extending longevity. In this review, we discuss recent papers showing the impact of autophagy on cell activity and age-associated diseases, highlighting the relevance of this process to the hallmarks of aging. Thus, understanding how autophagy plays an important role in aging opens new avenues for the discovery of biochemical and pharmacological targets and the development of novel anti-aging therapeutic approaches. Frontiers Media S.A. 2019-01-09 /pmc/articles/PMC6333684/ /pubmed/30687233 http://dx.doi.org/10.3389/fendo.2018.00790 Text en Copyright © 2019 Barbosa, Grosso and Fader. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Barbosa, María Carolina
Grosso, Rubén Adrián
Fader, Claudio Marcelo
Hallmarks of Aging: An Autophagic Perspective
title Hallmarks of Aging: An Autophagic Perspective
title_full Hallmarks of Aging: An Autophagic Perspective
title_fullStr Hallmarks of Aging: An Autophagic Perspective
title_full_unstemmed Hallmarks of Aging: An Autophagic Perspective
title_short Hallmarks of Aging: An Autophagic Perspective
title_sort hallmarks of aging: an autophagic perspective
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333684/
https://www.ncbi.nlm.nih.gov/pubmed/30687233
http://dx.doi.org/10.3389/fendo.2018.00790
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