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Dual endothelin receptor inhibition enhances T-DM1 efficacy in brain metastases from HER2-positive breast cancer
The effective treatment of cerebral metastases from HER2-positive breast cancer remains an unmet need. Recent studies indicate that activated astrocytes and brain endothelial cells exert chemoprotective effects on cancer cells through direct physical interaction. Here we report that the endothelin a...
Autores principales: | Askoxylakis, Vasileios, Ferraro, Gino B., Badeaux, Mark, Kodack, David P., Kirst, Isabelle, Shankaraiah, Ram C., Wong, Christina S. F., Duda, Dan G., Fukumura, Dai, Jain, Rakesh K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333771/ https://www.ncbi.nlm.nih.gov/pubmed/30675514 http://dx.doi.org/10.1038/s41523-018-0100-8 |
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