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Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2′-PO(4) recognition and ADP-ribosylation
Tpt1 is an essential agent of fungal tRNA splicing that removes the 2′-PO(4) at the splice junction generated by fungal tRNA ligase. Tpt1 catalyzes a unique two-step reaction whereby the 2′-PO(4) attacks NAD(+) to form an RNA-2′-phospho-ADP-ribosyl intermediate that undergoes transesterification to...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333775/ https://www.ncbi.nlm.nih.gov/pubmed/30644400 http://dx.doi.org/10.1038/s41467-018-08211-9 |