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Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2′-PO(4) recognition and ADP-ribosylation

Tpt1 is an essential agent of fungal tRNA splicing that removes the 2′-PO(4) at the splice junction generated by fungal tRNA ligase. Tpt1 catalyzes a unique two-step reaction whereby the 2′-PO(4) attacks NAD(+) to form an RNA-2′-phospho-ADP-ribosyl intermediate that undergoes transesterification to...

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Detalles Bibliográficos
Autores principales: Banerjee, Ankan, Munir, Annum, Abdullahu, Leonora, Damha, Masad J., Goldgur, Yehuda, Shuman, Stewart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333775/
https://www.ncbi.nlm.nih.gov/pubmed/30644400
http://dx.doi.org/10.1038/s41467-018-08211-9

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