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Discovering the pharmacodynamics of conolidine and cannabidiol using a cultured neuronal network based workflow
Determining the mechanism of action (MOA) of novel or naturally occurring compounds mostly relies on assays tailored for individual target proteins. Here we explore an alternative approach based on pattern matching response profiles obtained using cultured neuronal networks. Conolidine and cannabidi...
Autores principales: | Mendis, G. D. C., Berecki, G., Morrisroe, E., Pachernegg, S., Li, M., Varney, M., Osborne, P. B., Reid, C. A., Halgamuge, S., Petrou, S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333801/ https://www.ncbi.nlm.nih.gov/pubmed/30644434 http://dx.doi.org/10.1038/s41598-018-37138-w |
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