Cargando…

Dopamine D(2) receptor occupancy of lumateperone (ITI-007): a Positron Emission Tomography Study in patients with schizophrenia

Dopamine D(2) receptor occupancy (D(2)RO) is a key feature of all currently approved antipsychotic medications. However, antipsychotic efficacy associated with high D(2)RO is often limited by side effects such as motor disturbances and hyperprolactinemia. Lumateperone (ITI-007) is a first-in-class s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vanover, Kimberly E., Davis, Robert E., Zhou, Yun, Ye, Weiguo, Brašić, James R., Gapasin, Lorena, Saillard, Jelena, Weingart, Michal, Litman, Robert E., Mates, Sharon, Wong, Dean F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333832/ https://www.ncbi.nlm.nih.gov/pubmed/30449883 http://dx.doi.org/10.1038/s41386-018-0251-1

Ejemplares similares

S44. LUMATEPERONE (ITI-007) FOR THE TREATMENT OF SCHIZOPHRENIA: PLACEBO-CONTROLLED CLINICAL TRIALS AND AN OPEN-LABEL SAFETY SWITCHING STUDY
por: Vanover, Kimberly, et al.
Publicado: (2018)

F46. LUMATEPERONE (ITI-007): FAVORABLE SAFETY PROFILE IN AN OPEN LABEL SAFETY SWITCHING STUDY FROM STANDARD-OF-CARE ANTIPSYCHOTIC THERAPY IN PATIENTS WITH SCHIZOPHRENIA
por: Davis, Robert, et al.
Publicado: (2018)

M205. LONG-TERM SAFETY OF LUMATEPERONE (ITI-007): METABOLIC EFFECTS IN A 1-YEAR STUDY
por: Satlin, Andrew, et al.
Publicado: (2020)

Efficacy and Safety of Lumateperone for Treatment of Schizophrenia: A Randomized Clinical Trial
por: Correll, Christoph U., et al.
Publicado: (2020)

The role of lumateperone in the treatment of schizophrenia
por: Syed, Alveena Batool, et al.
Publicado: (2021)

T205. LUMATEPERONE IN THE TREATMENT OF SCHIZOPHRENIA: EVALUATION OF EXTRAPYRAMIDAL AND MOTOR SYMPTOMS IN 4 LATE-PHASE CLINICAL TRIALS
por: Durgam, Suresh, et al.
Publicado: (2020)

Safety and tolerability of lumateperone for the treatment of schizophrenia: a pooled analysis of late-phase placebo- and active-controlled clinical trials
por: Kane, John M, et al.
Publicado: (2021)

S221. THE EFFICACY OF LUMATEPERONE 42 MG IN THE TREATMENT OF SCHIZOPHRENIA SYMPTOMS ASSOCIATED WITH SOCIAL FUNCTIONING: POST HOC ANALYSIS OF AN ACUTE PLACEBO- AND ACTIVE-CONTROLLED TRIAL
por: Vanover, Kimberly, et al.
Publicado: (2020)

Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats
por: Snyder, Gretchen L., et al.
Publicado: (2016)

Immune Tolerance Induction (ITI) with a pdFVIII/VWF Concentrate (octanate) in 100 Patients in the Observational ITI (ObsITI) Study
por: Escuriola Ettingshausen, Carmen, et al.
Publicado: (2022)

Lumateperone Normalizes Pathological Levels of Acute Inflammation through Important Pathways Known to Be Involved in Mood Regulation
por: Dutheil, Sophie, et al.
Publicado: (2023)

Illuminating Hope for Mental Health: A Drug Review on Lumateperone
por: Tarzian, Martin, et al.
Publicado: (2023)

Dopamine Targeting Drugs for the Treatment of Schizophrenia: Past,  Present and Future
por: Li, Peng, et al.
Publicado: (2016)

iTi Conference in Turbulence 2018
por: Örlü, Ramis, et al.
Publicado: (2019)

6th iTi Conference
por: Peinke, Joachim, et al.
Publicado: (2016)

New synthesis of a late-stage tetracyclic key intermediate of lumateperone
por: Milen, Mátyás, et al.
Publicado: (2022)

Management of subjects with Intermittent Explosive Disorder and Autism Spectrum Disorder with Lumateperone
por: Mehdiratta, N., et al.
Publicado: (2023)

Newer antipsychotics: Brexpiprazole, cariprazine, and lumateperone: A pledge or another unkept promise?
por: Barman, Rajdip, et al.
Publicado: (2021)

7th iTi Conference in Turbulence
por: Örlü, Ramis, et al.
Publicado: (2017)

4th iTi Conference in Turbulence
por: Oberlack, Martin, et al.
Publicado: (2012)

Functional profile of a novel modulator of serotonin, dopamine, and glutamate neurotransmission
por: Snyder, Gretchen L., et al.
Publicado: (2014)

5th iTi Conference in Turbulence 2012
por: Talamelli, Alessandro, et al.
Publicado: (2014)

Genetic Dissection of the Ity3 Locus Identifies a Role for Ncf2 Co-Expression Modules and Suggests Selp as a Candidate Gene Underlying the Ity3.2 Locus
por: Khan, Rabia Tahir, et al.
Publicado: (2014)

Atypical Antipsychotic Lumateperone Effects on the Adrenal Gland With Possible Beneficial Effect of Quercetin Co-administration
por: El-Haroun, Hala, et al.
Publicado: (2021)

Questionnaire Survey of PHysical activITy in General Practitioners (PHIT GP Study)
por: McGrady, Finbar P, et al.
Publicado: (2007)

ITI Conference 2 : translators and interpreters mean business : proceedings of the second annual conference of the Institute of Translation and Interpreting, 29-30 April 1988, Hotel Russell, London
Publicado: (1988)

An open-label, positron emission tomography study of the striatal D(2)/D(3) receptor occupancy and pharmacokinetics of single-dose oral brexpiprazole in healthy participants
por: Wong, Dean F., et al.
Publicado: (2020)

Ity'an yik'oty iñatyibal ajCHolo' = Voz y conocimiento del pueblo CH'ol /
por: Guzmán López, Hilda
Publicado: (2013)

Correction to: An open-label, positron emission tomography study of the striatal D(2)/D(3) receptor occupancy and pharmacokinetics of single-dose oral brexpiprazole in healthy participants
por: Wong, Dean F., et al.
Publicado: (2021)

Complex(iti)es of the ubiquitous RNA-binding CSP41 proteins
por: Leister, Dario
Publicado: (2014)

Design of an anti-inflammatory diet (ITIS diet) for patients with rheumatoid arthritis
por: Bustamante, Marta F., et al.
Publicado: (2020)

Toxicities of Immune Checkpoint Inhibitors: Itis-Ending Adverse Reactions and More
por: Ellithi, Moataz, et al.
Publicado: (2020)

Positron Emission Tomography: A Tool for Identifying the Effects of Alcohol Dependence on the Brain
por: Wong, Dean F., et al.
Publicado: (2003)

Role of 5-HT(2A) receptor antagonists in the treatment of insomnia
por: Vanover, Kimberly E, et al.
Publicado: (2010)

Fine-Mapping and Phenotypic Analysis of the Ity3 Salmonella Susceptibility Locus Identify a Complex Genetic Structure
por: Khan, Rabia T., et al.
Publicado: (2014)

Can mean platelet volume IndIcate HelIcobacter posItIvIty and severIty of gastrIc InflammatIon? An orIgInal study and revIew of the lIterature
por: Akar, Tarik
Publicado: (2019)

A Familiar(ity) Problem: Assessing the Impact of Prerequisites and Content Familiarity on Student Learning
por: Shaffer, Justin F., et al.
Publicado: (2016)

Another level of complex-ity: The role of metabolic channeling and metabolons in plant terpenoid metabolism
por: Gutensohn, Michael, et al.
Publicado: (2022)

Brain PET Imaging of α7-nAChR with [18F]ASEM: Reproducibility, Occupancy, Receptor Density, and Changes in Schizophrenia
por: Wong, Dean F, et al.
Publicado: (2018)

ITI-Signals and Prelimbic Cortex Facilitate Avoidance Acquisition and Reduce Avoidance Latencies, Respectively, in Male WKY Rats
por: Beck, Kevin D., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_t68272t5i837n16e4gkdusqjum