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Neurocysticercosis in a rural population with extensive pig production in Angónia district, Tete Province, Mozambique

Neurocysticercosis (NCC) is an important neurological disease in countries with high prevalence of Taenia solium infection and is emerging as a serious public health and economic problem. The aim of this study was to estimate the prevalence of NCC in Angónia district, Tete province, Mozambique based...

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Autores principales: Assane, Yunus Amade, Trevisan, Chiara, Schutte, Clara Maria, Noormahomed, Emilia Virginia, Johansen, Maria Vang, Magnussen, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333921/
https://www.ncbi.nlm.nih.gov/pubmed/26519884
http://dx.doi.org/10.1016/j.actatropica.2015.10.018
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author Assane, Yunus Amade
Trevisan, Chiara
Schutte, Clara Maria
Noormahomed, Emilia Virginia
Johansen, Maria Vang
Magnussen, Pascal
author_facet Assane, Yunus Amade
Trevisan, Chiara
Schutte, Clara Maria
Noormahomed, Emilia Virginia
Johansen, Maria Vang
Magnussen, Pascal
author_sort Assane, Yunus Amade
collection PubMed
description Neurocysticercosis (NCC) is an important neurological disease in countries with high prevalence of Taenia solium infection and is emerging as a serious public health and economic problem. The aim of this study was to estimate the prevalence of NCC in Angónia district, Tete province, Mozambique based on: prevalence of human T. solium cysticercosis assessed by antigen Enzyme-linked Immunosorbent Assay (Ag-ELISA) seropositivity, history of epilepsy, and brain computed tomography (CT) scan results. A cross sectional study was conducted between September and November 2007 in Angónia district. Questionnaires and blood samples were collected from 1,723 study subjects. Brain CT-scans were carried out on 151 study subjects with confirmed history of epilepsy. A total of 77 (51.0% (95% CI, 42.7–59.2)) and 38 (25.2% (95% CI, 18.5–32.9)) subjects met the criteria for definitive and probable diagnosis of NCC, respectively. T. solium Ag-ELISA seropositivity was found in 15.5% (95% CI, 12.8–16.2) of the study subjects. The estimated life time prevalence of epilepsy was 8.8% (95% CI, 7.5–10.2). Highly suggestive lesions of NCC were found on CT-scanning in 77 (71.9%, (95% CI, 62.4–80.2)) of the seropositive and 8 (18.1%, (95% CI, 8.2–32.7)) of the seronegative study subjects, respectively. The present findings revealed a high prevalence of NCC among people with epilepsy in Angónia district. Determination of effective strategies for prevention and control of T. solium cysticercosis are necessary to reduce the burden of NCC among the affected populations.
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spelling pubmed-63339212019-01-16 Neurocysticercosis in a rural population with extensive pig production in Angónia district, Tete Province, Mozambique Assane, Yunus Amade Trevisan, Chiara Schutte, Clara Maria Noormahomed, Emilia Virginia Johansen, Maria Vang Magnussen, Pascal Acta Trop Article Neurocysticercosis (NCC) is an important neurological disease in countries with high prevalence of Taenia solium infection and is emerging as a serious public health and economic problem. The aim of this study was to estimate the prevalence of NCC in Angónia district, Tete province, Mozambique based on: prevalence of human T. solium cysticercosis assessed by antigen Enzyme-linked Immunosorbent Assay (Ag-ELISA) seropositivity, history of epilepsy, and brain computed tomography (CT) scan results. A cross sectional study was conducted between September and November 2007 in Angónia district. Questionnaires and blood samples were collected from 1,723 study subjects. Brain CT-scans were carried out on 151 study subjects with confirmed history of epilepsy. A total of 77 (51.0% (95% CI, 42.7–59.2)) and 38 (25.2% (95% CI, 18.5–32.9)) subjects met the criteria for definitive and probable diagnosis of NCC, respectively. T. solium Ag-ELISA seropositivity was found in 15.5% (95% CI, 12.8–16.2) of the study subjects. The estimated life time prevalence of epilepsy was 8.8% (95% CI, 7.5–10.2). Highly suggestive lesions of NCC were found on CT-scanning in 77 (71.9%, (95% CI, 62.4–80.2)) of the seropositive and 8 (18.1%, (95% CI, 8.2–32.7)) of the seronegative study subjects, respectively. The present findings revealed a high prevalence of NCC among people with epilepsy in Angónia district. Determination of effective strategies for prevention and control of T. solium cysticercosis are necessary to reduce the burden of NCC among the affected populations. 2015-10-28 2017-01 /pmc/articles/PMC6333921/ /pubmed/26519884 http://dx.doi.org/10.1016/j.actatropica.2015.10.018 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Assane, Yunus Amade
Trevisan, Chiara
Schutte, Clara Maria
Noormahomed, Emilia Virginia
Johansen, Maria Vang
Magnussen, Pascal
Neurocysticercosis in a rural population with extensive pig production in Angónia district, Tete Province, Mozambique
title Neurocysticercosis in a rural population with extensive pig production in Angónia district, Tete Province, Mozambique
title_full Neurocysticercosis in a rural population with extensive pig production in Angónia district, Tete Province, Mozambique
title_fullStr Neurocysticercosis in a rural population with extensive pig production in Angónia district, Tete Province, Mozambique
title_full_unstemmed Neurocysticercosis in a rural population with extensive pig production in Angónia district, Tete Province, Mozambique
title_short Neurocysticercosis in a rural population with extensive pig production in Angónia district, Tete Province, Mozambique
title_sort neurocysticercosis in a rural population with extensive pig production in angónia district, tete province, mozambique
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333921/
https://www.ncbi.nlm.nih.gov/pubmed/26519884
http://dx.doi.org/10.1016/j.actatropica.2015.10.018
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