Cargando…

Ginsenosides Act As Positive Modulators of P2X4 Receptors

We investigated the selectivity of protopanaxadiol ginsenosides from Panax ginseng acting as positive allosteric modulators on P2X receptors. ATP-induced responses were measured in stable cell lines overexpressing human P2X4 using a YOPRO-1 dye uptake assay, intracellular calcium measurements, and w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dhuna, Kshitija, Felgate, Matthew, Bidula, Stefan M., Walpole, Samuel, Bibic, Lucka, Cromer, Brett A., Angulo, Jesus, Sanderson, Julie, Stebbing, Martin J., Stokes, Leanne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334005/ https://www.ncbi.nlm.nih.gov/pubmed/30545933 http://dx.doi.org/10.1124/mol.118.113696

Ejemplares similares

P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology
por: Stokes, Leanne, et al.
Publicado: (2017)

Positive allosteric modulation of P2X7 promotes apoptotic cell death over lytic cell death responses in macrophages
por: Bidula, Stefan, et al.
Publicado: (2019)

Mapping a novel positive allosteric modulator binding site in the central vestibule region of human P2X7
por: Bidula, Stefan M., et al.
Publicado: (2019)

To Inhibit or Enhance? Is There a Benefit to Positive Allosteric Modulation of P2X Receptors?
por: Stokes, Leanne, et al.
Publicado: (2020)

Revisiting the Idea That Amyloid-β Peptide Acts as an Agonist for P2X7
por: Bibič, Lučka, et al.
Publicado: (2020)

Development of High-Throughput Fluorescent-Based Screens to Accelerate Discovery of P2X Inhibitors from Animal Venoms
por: Bibic, Lucka, et al.
Publicado: (2019)

Insights into the Structure-Activity Relationship of Glycosides as Positive Allosteric Modulators Acting on P2X7 Receptors
por: Piyasirananda, Waraporn, et al.
Publicado: (2021)

Design and development of stapled transmembrane peptides that disrupt the activity of G-protein–coupled receptor oligomers
por: Botta, Joaquín, et al.
Publicado: (2019)

Deriving Ligand Orientation in Weak Protein–Ligand Complexes by DEEP‐STD NMR Spectroscopy in the Absence of Protein Chemical‐Shift Assignment
por: Nepravishta, Ridvan, et al.
Publicado: (2018)

Effects of Minor Ginsenosides, Ginsenoside Metabolites, and Ginsenoside Epimers on the Growth of Caenorhabditis elegans
por: Lee, Joon-Hee, et al.
Publicado: (2011)

A 1-Year Study on Association between Peripherally Inserted Central Catheter Tip Position and Complications in Neonates
por: Patil, Kshitija, et al.
Publicado: (2020)

Ginsenoside Rg1 and astaxanthin act on the hypothalamus to protect female mice against reproductive aging
por: Dai, Xiaoman, et al.
Publicado: (2022)

Advances in Ginsenosides
por: Chen, Jen-Tsung
Publicado: (2020)

Intraconversion of Polar Ginsenosides, Their Transformation into Less-Polar Ginsenosides, and Ginsenoside Acetylation in Ginseng Flowers upon Baking and Steaming
por: Li, Xiang, et al.
Publicado: (2018)

Biotransformation of major ginsenosides in ginsenoside model culture by lactic acid bacteria
por: Park, Seong-Eun, et al.
Publicado: (2017)

Rk1, a Ginsenoside, Is a New Blocker of Vascular Leakage Acting through Actin Structure Remodeling
por: Maeng, Yong-Sun, et al.
Publicado: (2013)

Roles of ginsenosides in sepsis
por: Yu, Tao, et al.
Publicado: (2023)

Understanding the role of P2X7 in affective disorders—are glial cells the major players?
por: Stokes, Leanne, et al.
Publicado: (2015)

Progress in the Conversion of Ginsenoside Rb1 into Minor Ginsenosides Using β-Glucosidases
por: Zhu, Hongrong, et al.
Publicado: (2023)

Just-in-time deep learning for real-time X-ray computed tomography
por: Graas, Adriaan, et al.
Publicado: (2023)

Identification of selective protein–protein interaction inhibitors using efficient in silico peptide-directed ligand design
por: Beekman, Andrew M., et al.
Publicado: (2019)

Biotransformation of Ginsenoside Rb(1) to Prosapogenins, Gypenoside XVII, Ginsenoside Rd, Ginsenoside F(2), and Compound K by Leuconostoc mesenteroides DC102
por: Quan, Lin-Hu, et al.
Publicado: (2011)

Roles of ginsenosides in inflammasome activation
por: Yi, Young-Su
Publicado: (2019)

Biotechnological Interventions for Ginsenosides Production
por: Gantait, Saikat, et al.
Publicado: (2020)

Ginsenosides in Panax genus and their biosynthesis
por: Hou, Maoqi, et al.
Publicado: (2021)

Pharmacological Properties of Ginsenoside Re
por: Gao, Xiao-Yan, et al.
Publicado: (2022)

22nd Summer School and International Symposium on the Physics of Ionized Gases
por: Bibic, N, et al.
Publicado: (2004)

Kinetic study for the optimization of ginsenoside Rg3 production by heat treatment of ginsenoside Rb1
por: Vo, Hoang Tung, et al.
Publicado: (2015)

The interaction of serum albumin with ginsenoside Rh2 resulted in the downregulation of ginsenoside Rh2 cytotoxicity
por: Lin, Yingjia, et al.
Publicado: (2017)

Explorative Imaging and Its Implementation at the FleX-ray Laboratory
por: Coban, Sophia Bethany, et al.
Publicado: (2020)

Comparative Pharmacokinetics of Ginsenoside Rg(3) and Ginsenoside Rh(2) after Oral Administration of Ginsenoside Rg(3) in Normal and Walker 256 Tumor-bearing Rats
por: Fan, He, et al.
Publicado: (2016)

Platelet storage lesion: An update
por: Mittal, Kshitija, et al.
Publicado: (2015)

Dr. J. G. Jolly Emeritus Professor, Department of Transfusion Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh
por: Mittal, Kshitija, et al.
Publicado: (2014)

Exploring Multi‐Subsite Binding Pockets in Proteins: DEEP‐STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B
por: Monaco, Serena, et al.
Publicado: (2020)

A Sweet Response to a Sour Situation: The Role of Soluble Pattern Recognition Receptors in the Innate Immune Response to Invasive Aspergillus fumigatus Infections
por: Bidula, Stefan, et al.
Publicado: (2016)

Genomic Analysis of Non-B Nucleic Acids Structures in SARS-CoV-2: Potential Key Roles for These Structures in Mutability, Translation, and Replication?
por: Bidula, Stefan, et al.
Publicado: (2023)

Characterization of a Novel Ginsenoside MT1 Produced by an Enzymatic Transrhamnosylation of Protopanaxatriol-Type Ginsenosides Re
por: Jeon, Byeong-Min, et al.
Publicado: (2020)

Synthesis of ginsenoside Rb(1)-imprinted magnetic polymer nanoparticles for the extraction and cellular delivery of therapeutic ginsenosides
por: Liu, Kai-Hsi, et al.
Publicado: (2022)

Pharmacology of ginsenosides: a literature review
por: Leung, Kar Wah, et al.
Publicado: (2010)

Producing aglycons of ginsenosides in bakers' yeast
por: Dai, Zhubo, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_cho9ebrvbskieeor27jvrosduo