Contribution of Altered Endocannabinoid System to Overactive mTORC1 Signaling in Focal Cortical Dysplasia

Alterations of the PI3K/Akt/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway are causally involved in a subset of malformations of cortical development (MCDs) ranging from focal cortical dysplasia (FCD) to hemimegalencephaly and megalencephaly. These MCDs represent a frequent cause...

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Detalles Bibliográficos
Autores principales: García-Rincón, Daniel, Díaz-Alonso, Javier, Paraíso-Luna, Juan, Ortega, Zaira, Aguareles, José, de Salas-Quiroga, Adán, Jou, Cristina, de Prada, Inmaculada, Martínez-Cerdeño, Verónica, Aronica, Eleonora, Guzmán, Manuel, Pérez-Jiménez, María Ángeles, Galve-Roperh, Ismael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334222/
https://www.ncbi.nlm.nih.gov/pubmed/30687088
http://dx.doi.org/10.3389/fphar.2018.01508

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