p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value

Loss of p53 function is invariably associated with cancer. Its role in tumor growth was recently linked to its effects on cancer stem cells (CSCs), although the underlying molecular mechanisms remain unknown. Here, we show that c-myc is a transcriptional target of p53 in mammary stem cells (MaSCs) a...

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Detalles Bibliográficos
Autores principales: Santoro, Angela, Vlachou, Thalia, Luzi, Lucilla, Melloni, Giorgio, Mazzarella, Luca, D’Elia, Errico, Aobuli, Xieraili, Pasi, Cristina Elisabetta, Reavie, Linsey, Bonetti, Paola, Punzi, Simona, Casoli, Lucia, Sabò, Arianna, Moroni, Maria Cristina, Dellino, Gaetano Ivan, Amati, Bruno, Nicassio, Francesco, Lanfrancone, Luisa, Pelicci, Pier Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334229/
https://www.ncbi.nlm.nih.gov/pubmed/30650356
http://dx.doi.org/10.1016/j.celrep.2018.12.071

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