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Automated Pulmonary Nodule Classification in Computed Tomography Images Using a Deep Convolutional Neural Network Trained by Generative Adversarial Networks

Lung cancer is a leading cause of death worldwide. Although computed tomography (CT) examinations are frequently used for lung cancer diagnosis, it can be difficult to distinguish between benign and malignant pulmonary nodules on the basis of CT images alone. Therefore, a bronchoscopic biopsy may be...

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Autores principales: Onishi, Yuya, Teramoto, Atsushi, Tsujimoto, Masakazu, Tsukamoto, Tetsuya, Saito, Kuniaki, Toyama, Hiroshi, Imaizumi, Kazuyoshi, Fujita, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334309/
https://www.ncbi.nlm.nih.gov/pubmed/30719445
http://dx.doi.org/10.1155/2019/6051939
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author Onishi, Yuya
Teramoto, Atsushi
Tsujimoto, Masakazu
Tsukamoto, Tetsuya
Saito, Kuniaki
Toyama, Hiroshi
Imaizumi, Kazuyoshi
Fujita, Hiroshi
author_facet Onishi, Yuya
Teramoto, Atsushi
Tsujimoto, Masakazu
Tsukamoto, Tetsuya
Saito, Kuniaki
Toyama, Hiroshi
Imaizumi, Kazuyoshi
Fujita, Hiroshi
author_sort Onishi, Yuya
collection PubMed
description Lung cancer is a leading cause of death worldwide. Although computed tomography (CT) examinations are frequently used for lung cancer diagnosis, it can be difficult to distinguish between benign and malignant pulmonary nodules on the basis of CT images alone. Therefore, a bronchoscopic biopsy may be conducted if malignancy is suspected following CT examinations. However, biopsies are highly invasive, and patients with benign nodules may undergo many unnecessary biopsies. To prevent this, an imaging diagnosis with high classification accuracy is essential. In this study, we investigate the automated classification of pulmonary nodules in CT images using a deep convolutional neural network (DCNN). We use generative adversarial networks (GANs) to generate additional images when only small amounts of data are available, which is a common problem in medical research, and evaluate whether the classification accuracy is improved by generating a large amount of new pulmonary nodule images using the GAN. Using the proposed method, CT images of 60 cases with confirmed pathological diagnosis by biopsy are analyzed. The benign nodules assessed in this study are difficult for radiologists to differentiate because they cannot be rejected as being malignant. A volume of interest centered on the pulmonary nodule is extracted from the CT images, and further images are created using axial sections and augmented data. The DCNN is trained using nodule images generated by the GAN and then fine-tuned using the actual nodule images to allow the DCNN to distinguish between benign and malignant nodules. This pretraining and fine-tuning process makes it possible to distinguish 66.7% of benign nodules and 93.9% of malignant nodules. These results indicate that the proposed method improves the classification accuracy by approximately 20% in comparison with training using only the original images.
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spelling pubmed-63343092019-02-04 Automated Pulmonary Nodule Classification in Computed Tomography Images Using a Deep Convolutional Neural Network Trained by Generative Adversarial Networks Onishi, Yuya Teramoto, Atsushi Tsujimoto, Masakazu Tsukamoto, Tetsuya Saito, Kuniaki Toyama, Hiroshi Imaizumi, Kazuyoshi Fujita, Hiroshi Biomed Res Int Research Article Lung cancer is a leading cause of death worldwide. Although computed tomography (CT) examinations are frequently used for lung cancer diagnosis, it can be difficult to distinguish between benign and malignant pulmonary nodules on the basis of CT images alone. Therefore, a bronchoscopic biopsy may be conducted if malignancy is suspected following CT examinations. However, biopsies are highly invasive, and patients with benign nodules may undergo many unnecessary biopsies. To prevent this, an imaging diagnosis with high classification accuracy is essential. In this study, we investigate the automated classification of pulmonary nodules in CT images using a deep convolutional neural network (DCNN). We use generative adversarial networks (GANs) to generate additional images when only small amounts of data are available, which is a common problem in medical research, and evaluate whether the classification accuracy is improved by generating a large amount of new pulmonary nodule images using the GAN. Using the proposed method, CT images of 60 cases with confirmed pathological diagnosis by biopsy are analyzed. The benign nodules assessed in this study are difficult for radiologists to differentiate because they cannot be rejected as being malignant. A volume of interest centered on the pulmonary nodule is extracted from the CT images, and further images are created using axial sections and augmented data. The DCNN is trained using nodule images generated by the GAN and then fine-tuned using the actual nodule images to allow the DCNN to distinguish between benign and malignant nodules. This pretraining and fine-tuning process makes it possible to distinguish 66.7% of benign nodules and 93.9% of malignant nodules. These results indicate that the proposed method improves the classification accuracy by approximately 20% in comparison with training using only the original images. Hindawi 2019-01-02 /pmc/articles/PMC6334309/ /pubmed/30719445 http://dx.doi.org/10.1155/2019/6051939 Text en Copyright © 2019 Yuya Onishi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Onishi, Yuya
Teramoto, Atsushi
Tsujimoto, Masakazu
Tsukamoto, Tetsuya
Saito, Kuniaki
Toyama, Hiroshi
Imaizumi, Kazuyoshi
Fujita, Hiroshi
Automated Pulmonary Nodule Classification in Computed Tomography Images Using a Deep Convolutional Neural Network Trained by Generative Adversarial Networks
title Automated Pulmonary Nodule Classification in Computed Tomography Images Using a Deep Convolutional Neural Network Trained by Generative Adversarial Networks
title_full Automated Pulmonary Nodule Classification in Computed Tomography Images Using a Deep Convolutional Neural Network Trained by Generative Adversarial Networks
title_fullStr Automated Pulmonary Nodule Classification in Computed Tomography Images Using a Deep Convolutional Neural Network Trained by Generative Adversarial Networks
title_full_unstemmed Automated Pulmonary Nodule Classification in Computed Tomography Images Using a Deep Convolutional Neural Network Trained by Generative Adversarial Networks
title_short Automated Pulmonary Nodule Classification in Computed Tomography Images Using a Deep Convolutional Neural Network Trained by Generative Adversarial Networks
title_sort automated pulmonary nodule classification in computed tomography images using a deep convolutional neural network trained by generative adversarial networks
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334309/
https://www.ncbi.nlm.nih.gov/pubmed/30719445
http://dx.doi.org/10.1155/2019/6051939
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